Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes pregnancy compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes menstruation recovery or maintenance: compared with chemotherapy alone (very low certainty).

2 findings from 1 review

Any cold therapy vs no cold therapy following total knee replacement

Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes total adverse eventsAdverse events included discomfort, local skin… compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Exercise therapy vs adaptive pacing therapy

Participants with serious adverse reactions · men and women aged over 18 years with chronic fatigue syndrome

It is very uncertain whether exercise therapy changes participants with serious adverse reactions Measured after 52 weeks… compared with adaptive pacing therapy (very low certainty).

1 finding from 1 review