Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

136 questions · 140 findings · 17 reviews · Vascular

No studies found 22 · 15.7%GRADE not reported 13 · 9.3%Very low 28 · 20%Low 50 · 35.7%Moderate 18 · 12.9%High 9 · 6.4%

IM injection vs IA injection

Wound/ulcer healing: number of participants with healing ulcer · people with critical limb ischaemia

IM injection showed no clear difference in wound/ulcer healing: number of participants with healing ulcer compared with IA injection (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Deep vein thrombosis · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin probably leads to lower deep venous thrombosis compared with no prophylaxis or placebo (moderate certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Pulmonary embolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in pulmonary embolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Symptomatic venous thromboembolism · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin may leads to lower symptomatic venous thromboembolism compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Mortality due to other causes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in mortality due to other causes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no prophylaxis

Adverse outcomes · prevention of venous thromboembolism in patients with lower‐limb immobilization

Low molecular weight heparin showed no clear difference in adverse outcomes compared with no prophylaxis or placebo (low certainty).

1 finding from 1 review

Drug‐eluting balloon vs uncoated balloon angioplasty at 12 months

Amputation · people with peripheral arterial disease of the lower limbs

Drug‐eluting balloon showed no clear difference in amputation compared with uncoated balloon angioplasty at 12 months (high certainty).

1 finding from 1 review

Drug‐eluting balloon vs uncoated balloon angioplasty at 12 months

Primary vessel patency · people with peripheral arterial disease of the lower limbs

Drug‐eluting balloon leads to higher primary vessel patency compared with uncoated balloon angioplasty at 12 months (high certainty).

1 finding from 1 review