Surgical removal of the lesion (surgical excision, laser surgery, cryotherapy) vs Placebo or no treatment
Outcome not reported · People with a diagnosis of oral leukoplakia
The review found no eligible studies for this question.
1 finding from 1 review
'We did not identify any RCTs that compared surgical treatments with placebo or no treatment.' Three surgical RCTs were found (Chee 2013, Lopez-Jornet 2013, Schwarz 2005) but all excluded because they did not include a…
Studies not reported
No studies found
Maximum pain (verbal rating scale, VRS) · People requiring retreatment of periapical lesions (failed root canal therapy)
Placebo (sham irradiation, laser inactive) led to lower maximum pain (verbal rating scale, VRS) compared with control (no laser device used); GRADE not reported.
1 finding from 1 review
Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Laser (low level) showed no clear difference in oral mucositis (any severity) compared with placebo/sham/no treatment; GRADE not reported.
1 finding from 1 review
Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Laser (low level) showed no clear difference in oral mucositis (moderate to severe) compared with placebo/sham/no treatment; GRADE not reported.
1 finding from 1 review
RR 0.64 [0.38, 1.08]
2 studies
GRADE not reported
Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Laser (low level) led to lower oral mucositis (moderate to severe) compared with povidone; GRADE not reported.
1 finding from 1 review
Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Laser (low level) led to lower oral mucositis (severe) compared with placebo/sham/no treatment; GRADE not reported.
1 finding from 1 review
RR 0.2 [0.06, 0.62]
2 studies
GRADE not reported
Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies
Laser (low level) led to lower oral mucositis (severe) compared with povidone; GRADE not reported.
1 finding from 1 review
Laser fluorescence (LF) change · Patients with early caries lesions in permanent teeth (non-fluoridated water area)
For occlusal early caries lesions, adding CPP-ACP to fluorides produced significantly greater laser-fluorescence improvement than fluorides alone (favors the combination); not GRADE-rated.
2 findings from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 significantly improved remineralization versus control (SMD -0.56, 95% CI -0.96 to -0.15); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration significantly improved remineralization versus control (SMD -0.94, 95% CI -1.46 to -0.43), ranking second of seven therapies by SUCRA (88.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Combined self-assembling peptide P11-4 plus fluoride varnish significantly improved white spot lesion remineralization versus control (SMD -0.96, 95% CI -1.44 to -0.48) and ranked highest of seven therapies by SUCRA (89.7%); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Fluoride varnish (gold standard) did not differ significantly from control (SMD -0.25, 95% CI -0.51 to 0.02); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACP did not differ significantly from control (SMD -0.18, 95% CI -0.49 to 0.14); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACFP versus control gave SMD -0.42 (95% CI -0.84 to 0.00); the review classed CPP-ACFP as statistically significant versus control although the reported CI upper limit is at the null (0.00); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Self-reported joint pain when chewing · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Recurrence · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Depression · People with temporomandibular disorders (TMD)
Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
1 finding from 1 review
Severity of joint noise · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes severity of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
1 finding from 1 review
Participant satisfaction or quality of life · People with temporomandibular disorders (TMD)
Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes muscle pain when chewing compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
1 finding from 1 review