Findings

What do systematic reviews say?

68 questions · 69 findings · 6 reviews · Injuries

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No studies found 8 · 11.6%GRADE not reported 0 · 0%Very low 12 · 17.4%Low 38 · 55.1%Moderate 10 · 14.5%High 1 · 1.4%

Intervention not reported

TXA given intravenously at a total dose of 1 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…

1 finding from 1 review

Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a… 2024 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Low

Intervention not reported

TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…

1 finding from 1 review

Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a… 2024 · Cochrane Headline outcomes only
no estimate extracted
3 participants
Low

Intervention not reported

Hyponatraemia (serum sodium < 135 mmol/L) · children requiring intravenous fluid to maintain hydration

The intervention leads to lower hyponatraemia (serum sodium < 135 mmol/L) (high certainty).

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
RR 0.48 [0.38, 0.6]
10 studies · 970 participants
High

Intervention not reported

Hypernatraemia · children requiring intravenous fluid to maintain hydration

The intervention showed no clear difference in hypernatraemia (low certainty).

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
RR 1.24 [0.65, 2.38]
9 studies · 937 participants
Low

Intervention not reported

Death · children requiring intravenous fluid to maintain hydration

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 996 participants
Low

Intervention not reported

Seizures · children requiring intravenous fluid to maintain hydration

The intervention showed no clear difference in seizures (low certainty).

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
RR 0.62 [0.03, 15.02]
10 studies · 996 participants
Low

Intervention not reported

Cerebral oedema · children requiring intravenous fluid to maintain hydration

It is very uncertain whether the intervention changes cerebral oedema (very low certainty).

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 9 participants
Very low

Intervention not reported

Overhydration · children requiring intravenous fluid to maintain hydration

The intervention showed no clear difference in overhydration (low certainty).

1 finding from 1 review

Isotonic versus hypotonic solutions for maintenance intravenous fluid administration in children 2014 · Cochrane Headline outcomes only
RR 1.14 [0.46, 2.87]
5 studies · 615 participants
Low