Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… changes caries presence in primary teeth compared with placebo (very low certainty).
1 finding from 1 review
Child microbiological presence (mutans streptococci acquisition) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review
d1-4 efs · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review
Health service and/or policy intervention designed to modify access to oral health information or services for pregnant women, new mothers or other primary caregivers vs Standard care (or any comparator)
Outcome not reported · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
The review found no eligible studies for this question.
1 finding from 1 review
Mother caries (DMFT increment) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… showed no clear difference in mother caries (DMFT increment) compared with placebo; GRADE not reported.
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
It is very uncertain whether dietary advice on how to achieve a healthy diet for infants… changes caries presence in primary teeth compared with standard care (very low certainty).
1 finding from 1 review
Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
The review found no eligible studies for this question.
2 findings from 1 review
Child microbiological presence (any mutans streptococci colonisation) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Package of oral health education/promotion including oral hygiene… showed no clear difference in child microbiological presence (mutans streptococci colonisation) compared with standard care; GRADE not reported.
1 finding from 1 review
Yu 2021: MS colonisation level (CFU x10^4) lower with intervention at 2 yrs (MD -2.80) and 3 yrs (MD -15, 95% CI -27.75 to -2.25) but not 1 yr (MD -0.20, 95% CI -0.50 to 0.10); MS-to-total-bacteria ratio lower at 1 yr…
1 study
GRADE not reported
SiC30 index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
Package of oral health education/promotion including oral hygiene… led to lower siC30 index score compared with standard care; GRADE not reported.
1 finding from 1 review
Mother caries (dmfs increment) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… showed no clear difference in mother caries (dmfs increment) compared with placebo; GRADE not reported.
1 finding from 1 review
Caries arrestment at the surface level · Children and adults without systemic diseases affecting dental health
SDF showed no clear advantage for caries arrestment at the surface level.
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults without systemic diseases affecting dental health
SDF showed a higher caries-arrestment proportion at the individual level, but the reported difference was not statistically significant.
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults without systemic diseases affecting dental health
SDF showed a higher caries-free proportion at the tooth level, but the reported difference was not statistically significant.
1 finding from 1 review
Intervention not reported
Treatment failure (time-to-failure, 7 years)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Radiographic proximal caries lesion progression · Children with non-cavitated proximal caries lesions in primary teeth (ages 5-8)
In one trial, glass ionomer varnish showed no statistically significant difference versus non-invasive care in radiographic proximal caries progression (OR 0.58, CI includes 1; ungraded subgroup).
1 finding from 1 review
Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
Pooling 2 trials, resin-based sealants reduced radiographic proximal caries progression versus non-invasive measures (OR 0.24; ungraded subgroup).
1 finding from 1 review
Adverse events and periodontal/secondary outcomes (gingival bleeding, gingival bleeding index, visible plaque index) · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
Only three trials reported secondary/adverse outcomes; no adverse events were attributed to microinvasive treatment and periodontal findings were mixed and not pooled (ungraded).
1 finding from 1 review
Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth- systematic… 2025 All outcomesBaseline and follow-up · Multiple countries (Brazil, Saudi Arabia, Netherlands, USA, Turkey, Switzerland, Germany, New Zealand, Chile, Thailand); dental clinic/community settings
Reported narratively by 3 trials (Arthur 2018, Sarti 2020, Jorge 2019). No adverse events were attributed to microinvasive treatment. Gingival bleeding index: no significant difference in Arthur 2018 and Jorge 2019 but…
3 studies
GRADE not reported
Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
Pooling 10 trials, resin infiltration reduced radiographic proximal caries progression versus non-invasive measures (OR 0.23); this subgroup was not separately GRADE-rated.
1 finding from 1 review
Radiographic proximal caries lesion progression · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages 3-45)
No eligible studies compared microinvasive techniques with invasive (restorative) treatment; this planned comparison had zero included studies.
1 finding from 1 review
Radiographic proximal caries lesion progression · Children with non-cavitated proximal caries lesions in primary teeth (ages 3-9)
In primary teeth (5 trials), microinvasive techniques reduced radiographic proximal caries progression versus non-invasive measures (OR 0.38; ungraded subgroup).
1 finding from 1 review