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Evidence found and GRADE certainty

154 questions · 161 findings · 14 reviews · Neuromuscular

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No studies found 47 · 29.2%GRADE not reported 7 · 4.3%Very low 52 · 32.3%Low 33 · 20.5%Moderate 13 · 8.1%High 9 · 5.6%

Intervention not reported

Health‐related quality of life · participants with CTEV at initial presentation
1 finding from 1 review

Intervention not reported

Adverse events · participants with CTEV at initial presentation

The intervention may leads to lower adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Function · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Gait assessment · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · participants with resistant CTEV

The review found no eligible studies for this question.

1 finding from 1 review

Botulinum toxin plus conservative treatment vs conservative treatment

Improvement (greater than 50% of time spent) heel‐toe walking Measured by parents' perception of toe walking frequency more than 50% of the time. · children with ITW gait

It is very uncertain whether botulinum toxin plus conservative treatment changes improvement (greater than 50% of time spent) heel‐toe walking… compared with conservative treatment only (very low certainty).

1 finding from 1 review

Botulinum toxin plus conservative treatment vs conservative treatment

Recurrence of ITW post‐treatment Assessed by improvement in toe walking based on Gait Analysis Classification An increase indicates improvement (an improvement indicated by a change in downgrading of the severe or 3, moderate or 2, and mild or 1 c... · children with ITW gait
1 finding from 1 review

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Change in cardiac function: number of patients with EF < 45% · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

It is very uncertain whether prophylactic perindopril (2 mg to 4 mg daily) changes change in cardiac function: number of patients with EF < 45% compared with placebo (very low certainty).

1 finding from 1 review