What do systematic reviews say?

Physical activity vs no physical activity

• Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 247 participants
  Low

Physical activity vs no physical activity

• Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 251 participants
  Low

Physical activity vs no physical activity

• Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 117 participants
  High

Physical activity vs no physical activity

• Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 91 participants
  Moderate

Physical activity vs no physical activity

• Physical activity and exercise training in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 156 participants
  Low

Oscillating devices vs breathing techniques

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 114 participants
  Low

Oscillating devices vs conventional physiotherapy

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 345 participants
  Very low

Oscillating devices vs different oscillating devices

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 265 participants
  Very low

Oscillating devices vs PEP

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 242 participants
  Very low

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs standard local care

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in number of participants with postoperative bleedings requiring… compared with standard care (usual local haemostatic measures: gelatin sponge and… (moderate certainty).

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD 0.02 [-0.07, 0.11]
  2 studies · 125 participants
  Moderate

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… led to lower number of immediate and delayed postoperative bleeding episodes… compared with placebo (placebo solution/mouthwash); GRADE not reported.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  Immediate (<24 h) and delayed (24 h to 10 days); bleeds occurred 1, 3 or 5 days postoperatively
  RD -0.22 [-0.35, -0.10]
  1 study · 89 participants
  GRADE not reported

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… probably leads to lower number of participants with postoperative bleedings requiring… compared with placebo (placebo solution/mouthwash) (moderate certainty).

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes

  7 days
  RD -0.25 [-0.36, -0.14]
  2 studies · 128 participants
  Moderate

Summary of findings ‐ computerised learning vs no intervention

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Very low

Summary of findings ‐ computerised learning vs no intervention

The review found no eligible studies for this question.

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ computerised learning vs no intervention

The review found no eligible studies for this question.

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ computerised learning vs no intervention

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 87 participants
  Very low

Summary of findings ‐ computerised learning vs no intervention

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 47 participants
  Low

Recombinant human growth hormone vs placebo or no intervention

Summary of findings ‐ recombinant growth hormone showed no clear difference in longitudinal growth: change in height SDS compared with placebo or no intervention (low certainty).

• Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
  MD 0
  2 studies · 20 participants
  Low

Recombinant human growth hormone vs placebo or no intervention

It is very uncertain whether summary of findings ‐ recombinant growth hormone changes measures of mineral metabolism: change in serum phosphate mmol/L compared with placebo or no intervention (very low certainty).

• Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
  MD 0.18 [0.08, 0.28]
  2 studies · 20 participants
  Very low

Recombinant human growth hormone vs placebo or no intervention

• Recombinant growth hormone therapy for X‐linked hypophosphatemia in children 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 20 participants
  Low