Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with NIPPV or NIV (low certainty).
1 finding from 1 review
In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with NIPPV or NIV (low certainty).
1 finding from 1 review
Intervention not reported
Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
It is very uncertain whether the intervention changes mortality at longest (very low certainty).
1 finding from 1 review
Intervention not reported
Number of days ventilated · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
1 finding from 1 review
Intervention not reported
Requirement for inotropic support (scale from 0 to 28, days of catecholamine use) · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
1 finding from 1 review
Intervention not reported
Requirement for renal replacement therapy ( · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
It is very uncertain whether the intervention changes requirement for renal replacement therapy ( (very low certainty).
1 finding from 1 review
Intervention not reported
Quality of life · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…
1 finding from 1 review
no estimate extracted
0 participants
GRADE not reported
Duration of mechanical ventilation · mechanically ventilated ICU adults and children requiring sedation management
1 finding from 1 review
ICU mortality · mechanically ventilated ICU adults and children requiring sedation management
Protocol‐directed sedation management showed no clear difference in ICU mortality compared with usual care (low certainty).
1 finding from 1 review
Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management
Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).
1 finding from 1 review
Duration of ICU stay · mechanically ventilated ICU adults and children requiring sedation management
1 finding from 1 review
Length of hospital stay · mechanically ventilated ICU adults and children requiring sedation management
1 finding from 1 review
Adverse event ‐ incidence of self‐extubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management
Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of self‐extubation (in ICU) compared with usual care (high certainty).
1 finding from 1 review
Adverse event ‐ incidence of reintubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management
Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of reintubation (in ICU) compared with usual care (low certainty).
1 finding from 1 review
Incidence of tracheostomy (in ICU) · mechanically ventilated ICU adults and children requiring sedation management
Protocol‐directed sedation management showed no clear difference in incidence of tracheostomy (in ICU) compared with usual care (low certainty).
1 finding from 1 review
Number of delirium ‐ and coma‐free days (within 28 days) measured by CAM‐ICU or ICDSC · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…
1 finding from 1 review
Ventilator‐free days (within the first 30 days) · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…
1 finding from 1 review
Duration of ICU stay · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…
It is very uncertain whether physical and cognitive therapy changes length of ICU stay (days) compared with standard care (very low certainty).
1 finding from 1 review
Cognitive function · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…
1 finding from 1 review
Cognitive functioning b) Executve functioning (DEX score) (scores range from 0 to 80. Lower scores indicate better functioning) (DEX) · critically ill patients 18 years or older treated for respiratory failure or septic or both, cardiogenic or haemorrhagic shock who resided…
1 finding from 1 review