Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

347 questions · 354 findings · 22 reviews

No studies found 100 · 28.2%GRADE not reported 37 · 10.5%Very low 115 · 32.5%Low 64 · 18.1%Moderate 23 · 6.5%High 15 · 4.2%

HALOPERIDOL vs chlorpromazine

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ cardiovascular ‐ hypotension compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects: specific ‐ seizure · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ central nervous system ‐ seizures compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs PLACEBO/NIL

Repeated need for tranquillisation ‐ needing additional injections during 24 hours · patients with psychosis‐induced aggression or agitation

HALOPERIDOL may leads to lower repeated need for tranquillisation needing additional injection… compared with PLACEBO/NIL (low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Tranquillisation or asleep ‐ not asleep up to 2 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in tranquillisation or asleep ‐ not asleep up to 2 hours compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Repeated need for rapid tranquillisation ‐ more than 1 injection · psychosis‐induced aggression or agitation

HALOPERIDOL probably leads to higher repeated need for rapid tranquillisation ‐ more than 1 injection compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

Global outcome ‐ need for benzodiazepine during 24 hours · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in global outcome ‐ need for benzodiazepine compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Tranquillisation or asleep ‐ not asleep by 12 hours · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes tranquillisation or asleep ‐ not asleep by 12 hours compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Global outcome: specific Not sedated at 60 minutes * · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: specific Not sedated at 60 minutes * compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Specific behaviour ‐ Aggression ‐ no overall improvement · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviour ‐ aggression ‐ no overall improvement compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Adverse effects: Specific ‐ dystonia between 0‐3 days (IM phase) · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia between 0‐3 days (IM phase) compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Adverse effects: Specific ‐ rigidity between 0‐3 days (IM phase) · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ rigidity between 0‐3 days (IM phase) compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review