Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

259 questions · 268 findings · 33 reviews

No studies found 56 · 20.9%GRADE not reported 21 · 7.8%Very low 68 · 25.4%Low 64 · 23.9%Moderate 49 · 18.3%High 10 · 3.7%

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs cow's milk formula

Eczema ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes eczema ‐ childhood (incidence) compared with cow's milk formula ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Chlorhexidine oral product (one formulation/concentration) vs Another chlorhexidine formulation, concentration or application frequency

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

All allergic disease ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes all allergic disease ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Asthma ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes asthma ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Eczema ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes eczema ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Food allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes food allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ infancy (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ infancy (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Early short‐term feeding: hydrolysed formula vs human milk feeding ‐ low‐risk infants

Cow's milk allergy ‐ childhood (incidence) · infants not selected for allergic disease risk.

It is very uncertain whether early short‐term feeding: hydrolysed formula changes cow's milk allergy ‐ childhood (incidence) compared with human milk feeding ‐ low‐risk infants (very low certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Virologic failure 2 successive HIV‐1 RNA >= 200copies/ml at 16+ weeks after randomisation · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in virologic failure 2 successive HIV‐1 RNA >= 200copies/ml at 16+… compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Virologic suppression Viral load < 50 copies/ml · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in virologic suppression Viral load < 50 copies/ml compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review

Co‐formulated abacavir‐lamivudine‐zidovudine vs NNRTIs or PIs

Severe adverse events · patients with initial treatment of HIV infection in antiretroviral‐naive individuals

Co‐formulated abacavir‐lamivudine‐zidovudine showed no clear difference in severe adverse events compared with NNRTIs or PIs (moderate certainty).

1 finding from 1 review