Findings

What do systematic reviews say?

203 questions · 208 findings · 26 reviews · Neonatal

Sort:Best matchNewest Highest certainty Download CSV

No studies found 3 · 1.4%GRADE not reported 23 · 11.1%Very low 59 · 28.4%Low 107 · 51.4%Moderate 12 · 5.8%High 4 · 1.9%

Fish oil lipid emulsion (LE) vs another fish oil LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.96 [0.06, 14.65]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Death at hospital discharge · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.15, 6.64]
1 study · 60 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.16 [0.4, 3.35]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MOFS‐LE vs… compared with another fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.69 [0.56, 5.11]
1 study · 55 participants
Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 55 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Growth rate – MS‐LE vs S‐LE · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (any definition) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.26, 3.86]
4 studies · 261 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.15, 6.82]
2 studies · 159 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE vs non‐fish oil LE (combined subgroups) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.61 [0.24, 1.56]
4 studies · 328 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Death at hospital discharge · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in death before discharge – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.21, 4.82]
3 studies · 224 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Death of baby (up to discharge) · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs S‐LE

Any ROP – OS‐LE vs S‐LE · Parenterally fed preterm infants

It is very uncertain whether alternative lipid emulsion (LE) changes any ROP – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.98 [0.67, 1.43]
3 studies · 142 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Culture‐positive sepsis · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in culture‐positive sepsis – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.22 [0.54, 2.78]
2 studies · 164 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 310 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 2.9 [0.12, 68.5]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Death at hospital discharge · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs another alternative‐LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MS‐LE vs… compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.77 [0.23, 2.6]
1 study · 59 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition: low and unclear risk of bias studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition: low and unclear risk of bias… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.8 [0.53, 1.21]
10 studies · 1024 participants
Low