Findings

What do systematic reviews say?

73 questions · 73 findings · 3 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 37 · 50.7%GRADE not reported 0 · 0%Very low 13 · 17.8%Low 15 · 20.5%Moderate 8 · 11%High 0 · 0%

Autogenic drainage vs conventional physiotherapy

Need for extra treatment · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 36 participants
Very low

Autogenic drainage vs spontaneous cough

FEV1 % predicted · adults and children with CF

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Autogenic drainage vs spontaneous cough

QoL · adults and children with CF

The review found no eligible studies for this question.

1 finding from 1 review

Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Isoxsuprine vs placebo

Ulcer healing · individuals with sickle cell disease and a leg ulcer

It is very uncertain whether isoxsuprine changes complete leg ulcer closure (defined as 100% epithelization or skin… compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
RR 1.2 [0.4, 3.62]
1 study · 40 participants
Very low

Propionyl‐L‐carnitine vs placebo

Complete leg ulcer closure ‐ not reported · individuals with sickle cell disease and a leg ulcer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Arginine butyrate plus standard care alone vs usual care

Ulcer healing · individuals with sickle cell disease and a leg ulcer

It is very uncertain whether arginine butyrate plus standard care alone changes complete leg ulcer closure (defined as 100% epithelization or skin… compared with standard care alone (very low certainty).

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
RR 3.72 [0.9, 15.35]
1 study · 23 participants
Very low

Intervention not reported

Appearance or exacerbation of gastroesophageal reflux episode: clinical test · infants and young children with cystic fibrosis

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 40 participants
Moderate

Intervention not reported

Appearance or exacerbation of gastroesophageal reflux episodes: pulmonary events · infants and young children with cystic fibrosis

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Peripheral oxygen saturation (%) · infants and young children with cystic fibrosis

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Moderate

Intervention not reported

Number of exacerbations of upper respiratory tract symptoms · infants and young children with cystic fibrosis

The intervention showed no clear difference in number of exacerbations of upper respiratory tract symptoms (moderate certainty).

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

Intervention not reported

Number of days on antibiotics for acute exacerbations · infants and young children with cystic fibrosis

The intervention showed no clear difference in number of days on antibiotics for acute exacerbations (moderate certainty).

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

Intervention not reported

Chest X‐ray scores · infants and young children with cystic fibrosis

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Moderate

Intervention not reported

Pulmonary function test (FVC) % predicted · infants and young children with cystic fibrosis

The intervention showed no clear difference in pulmonary function test (FVC) % predicted (moderate certainty).

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
MD 16
1 study · 14 participants
Moderate