Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

212 questions · 231 findings · 16 reviews

No studies found 50 · 21.6%GRADE not reported 58 · 25.1%Very low 41 · 17.7%Low 42 · 18.2%Moderate 25 · 10.8%High 15 · 6.5%

Doxycycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

3 findings from 1 review

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Mean VAS pain per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in mean VAS pain per day compared with placebo; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Total number of new ulcers over 90 days · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower total number of new ulcers over 90 days compared with placebo; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Number of ulcers at end of 90-day treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in number of ulcers at end of 90-day treatment compared with placebo; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower number of new lesions per day compared with placebo; GRADE not reported.

1 finding from 1 review

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing attachment level (PAL) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review