Findings

What do systematic reviews say?

212 questions · 231 findings · 16 reviews

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No studies found 50 · 21.6%GRADE not reported 58 · 25.1%Very low 41 · 17.7%Low 42 · 18.2%Moderate 25 · 10.8%High 15 · 6.5%

Doxycycline 40 mg vs placebo

Proportion of participants with adverse event · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 537 participants
High

Doxycycline 40 mg vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 537 participants
High

Doxycycline 40 mg vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 537 participants
High

Doxycycline 40 mg vs placebo

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 537 participants
Moderate

Doxycycline 40 mg vs placebo

Time needed until improvement of the skin lesions · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 537 participants
High

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline+Rifampicin vs Quinolones+Rifampicin

total treatment failure · patients with human Brucellosis

Doxycycline+Rifampicin showed no clear difference in total treatment failure compared with quinolones+Rifampicin (moderate certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
OR 0.94 [0.45, 1.98]
3 studies · 181 participants
Moderate

Doxycycline+Rifampicin vs Quinolones+Rifampicin

Minor adverse drug reactions · patients with human Brucellosis

Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with quinolones+Rifampicin (low certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
RR 1.8 [0.78, 4.18]
4 studies · 296 participants
Low

Intervention not reported

Doxycycline (4 RCTs; 308 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 308 participants
Low

Intervention not reported

Doxycycline (4 RCTs, 308 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 308 participants
Low

Intervention not reported

Doxycycline · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Doxycycline (1 RCT, 80 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Very low

Intervention not reported

Doxycycline · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Doxycycline (5 RCTs, 117 participants) · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

1 finding from 1 review

Interventions for the management of malignant pleural effusions: a network meta‐analysis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 117 participants
Low

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Mean VAS pain per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in mean VAS pain per day compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
MD -5.00 [-11.93, 1.93]
1 study · 50 participants
GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Total number of new ulcers over 90 days · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower total number of new ulcers over 90 days compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
MD -16.40 [-30.44, -2.36]
1 study · 50 participants
GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
No differences in adverse events were reported.
1 study · 50 participants
GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Number of ulcers at end of 90-day treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in number of ulcers at end of 90-day treatment compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
MD -0.5 [-1.10, 0.10]
1 study · 50 participants
GRADE not reported

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Average number of new lesions per week · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) led to lower number of new lesions per day compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
90 days
MD -0.19 [-0.35, -0.03]
1 study · 50 participants
GRADE not reported

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox) added to manual debridement vs Manual debridement plus chlorhexidine irrigation/gel

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing attachment level (PAL) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.

1 finding from 1 review

Interventions for replacing missing teeth: treatment of peri‐implantitis 2012 · Cochrane All outcomes
4 months (18 weeks)
MD 0.61 [0.40, 0.82]
1 study · 28 participants
GRADE not reported