Findings

What do systematic reviews say?

84 questions · 86 findings · 8 reviews

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No studies found 9 · 10.5%GRADE not reported 5 · 5.8%Very low 12 · 14%Low 28 · 32.6%Moderate 23 · 26.7%High 9 · 10.5%

Summary of findings: levodopa vs other dopamine agonists

Quality of sleep · patients with restless legs syndrome

1 finding from 1 review

Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 344 participants
Low

Summary of findings: levodopa vs other dopamine agonists

QoL · patients with restless legs syndrome

1 finding from 1 review

Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 314 participants
Moderate

Summary of findings: levodopa vs other dopamine agonists

IRLS · patients with restless legs syndrome

1 finding from 1 review

Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 383 participants
Moderate

Summary of findings: levodopa vs other dopamine agonists

Periodic limb movements per hour of time in bed · patients with restless legs syndrome

1 finding from 1 review

Levodopa for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 39 participants
Low

Bromocriptine vs no treatment

Miscarriage · women with idiopathic hyperprolactinemia and recurrent miscarriage history

Bromocriptine may leads to lower miscarriages compared with no treatment (low certainty).

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
RR 0.28 [0.09, 0.87]
1 study · 46 participants
Low

Bromocriptine vs no treatment

Live birth · women with idiopathic hyperprolactinemia and recurrent miscarriage history

It is very uncertain whether bromocriptine changes live births compared with no treatment (very low certainty).

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
RR 1.5 [0.93, 2.42]
1 study · 46 participants
Very low

Bromocriptine vs no treatment

Conception · women with idiopathic hyperprolactinemia and recurrent miscarriage history

It is very uncertain whether bromocriptine changes conception compared with no treatment (very low certainty).

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
RR 0.92 [0.77, 1.09]
1 study · 46 participants
Very low

Bromocriptine vs no treatment

Proportion reduction in serum prolactin levels · women with idiopathic hyperprolactinemia and recurrent miscarriage history

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Bromocriptine vs no treatment

Serum prolactin normalization · women with idiopathic hyperprolactinemia and recurrent miscarriage history

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Bromocriptine vs no treatment

Maternal adverse events · women with idiopathic hyperprolactinemia and recurrent miscarriage history

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Bromocriptine vs no treatment

Adverse fetal outcomes · women with idiopathic hyperprolactinemia and recurrent miscarriage history

1 finding from 1 review

Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent… 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Amantidine vs antidepressants

Leaving the study early · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in dropouts compared with antidepressants (moderate certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.86 [0.48, 1.53]
4 studies · 153 participants
Moderate

Amantidine vs antidepressants

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.56 [0.18, 1.77]
2 studies · 44 participants
Low

Amantidine vs antidepressants

Abstinence · patients with the treatment of cocaine dependence

Amantidine may leads to lower abstinence (objective) N of subjects abstinent at the end of the study compared with antidepressants (low certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.25 [0.12, 0.53]
2 studies · 68 participants
Low

Amantadine vs placebo

Leaving the study early · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in dropouts compared with placebo (moderate certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 0.98 [0.77, 1.26]
9 studies · 484 participants
Moderate

Amantadine vs placebo

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in adverse events as N of participants with at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 1.19 [0.69, 2.06]
4 studies · 128 participants
Moderate

Amantadine vs placebo

Abstinence · patients with the treatment of cocaine dependence

Amantadine showed no clear difference in abstinence (objective) N of subjects abstinent at the end of the study compared with placebo (low certainty).

2 findings from 1 review

Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 1.13 [0.59, 2.13]
5 studies · 275 participants
Low
Dopamine agonists for the treatment of cocaine dependence 2015 · Cochrane Headline outcomes only
RR 1.49 [1.03, 2.15]
3 studies · 76 participants
Moderate

Intervention not reported

IRLS cabergoline · patients with restless legs syndrome

1 finding from 1 review

Dopamine agonists for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
High

Intervention not reported

IRLS lisuride · patients with restless legs syndrome

1 finding from 1 review

Dopamine agonists for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 378 participants
High

Intervention not reported

IRLS pergolide · patients with restless legs syndrome

1 finding from 1 review

Dopamine agonists for the treatment of restless legs syndrome 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 97 participants
High