Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

139 questions · 139 findings · 11 reviews · Schizophrenia

No studies found 22 · 15.8%GRADE not reported 31 · 22.3%Very low 56 · 40.3%Low 24 · 17.3%Moderate 6 · 4.3%High 0 · 0%

COGNITIVE BEHAVIOUR THERAPY + MOTIVATIONAL INTERVIEWING vs usual care

Relapse · people with both severe mental illness and substance misuse

It is very uncertain whether cognitive behavioural therapy + motivational interviewing changes relapse:* Relapse at 3 months after 9 months of treatment compared with standard care (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + supportive intervention vs non‐directive reflective listening + supportive intervention

Prodromal symptoms: transition to psychosis Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes prodromal symptoms: transition to psychosis Endpoint data (events) compared with non‐directive reflective listening + supportive intervention (very low certainty).

1 finding from 1 review