Findings

What do systematic reviews say?

67 questions · 80 findings · 8 reviews · Gynaecology and Fertility

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No studies found 7 · 8.8%GRADE not reported 1 · 1.3%Very low 16 · 20%Low 41 · 51.3%Moderate 15 · 18.8%High 0 · 0%

Metformin vs clomiphene

Miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.61 [0.27, 1.38]
2 studies · 500 participants
Low

Metformin vs clomiphene

Menstrual frequency per woman · women with polycystic ovary syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Metformin vs clomiphene

Miscarriage · women with polycystic ovary syndrome

It is very uncertain whether metformin changes miscarriage rate per woman compared with clomiphene citrate (very low certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.92 [0.5, 1.67]
5 studies · 741 participants
Very low

hCG vs no ovulation trigger

Live birth rate Live fetus delivered beyond 20 completed weeks' gestation · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in live birth rate Live fetus delivered beyond 20 completed weeks'… compared with no ovulation trigger (low certainty).

1 finding from 1 review

Ovulation triggers in anovulatory women undergoing ovulation induction 2014 · Cochrane Headline outcomes only
OR 0.97 [0.52, 1.83]
305 participants
Low

hCG vs no ovulation trigger

Ovulation rate Ultrasound evidence of collapsed follicle or mid‐luteal serum progesterone < 10 ng/mL · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in ovulation rate Ultrasound evidence of collapsed follicle or… compared with no ovulation trigger (low certainty).

1 finding from 1 review

Ovulation triggers in anovulatory women undergoing ovulation induction 2014 · Cochrane Headline outcomes only
OR 0.99 [0.36, 2.77]
305 participants
Low

hCG vs no ovulation trigger

Clinical pregnancy · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in clinical pregnancy rate Ultrasound evidence of pregnancy compared with no ovulation trigger (low certainty).

1 finding from 1 review

Ovulation triggers in anovulatory women undergoing ovulation induction 2014 · Cochrane Headline outcomes only
OR 1.02 [0.56, 1.89]
305 participants
Low

hCG vs no ovulation trigger

Miscarriage per clinical pregnancy · women with anovulatory infertility undergoing ovulation induction with clomiphene citrate

Human chorionic gonadotrophin showed no clear difference in miscarriage rate per clinical pregnancy Spontaneous pregnancy loss… compared with no ovulation trigger (low certainty).

1 finding from 1 review

Ovulation triggers in anovulatory women undergoing ovulation induction 2014 · Cochrane Headline outcomes only
OR 1.19 [0.17, 8.23]
54 participants
Low