Dentin bridge formation · Patients with carious pulp exposure in permanent teeth undergoing partial pulpotomy
Evidence on dentin bridge formation for calcium hydroxide versus MTA is weak and imprecise, with no material shown superior (4 RCTs, not pooled; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than CEM (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than calcium hydroxide (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure
Biodentine had a significantly higher pulpotomy success rate than MTA (indirect comparison; numeric estimate not available); ungraded.
1 finding from 1 review
MMP-8 expression/activity · Human carious dentin
MMP-8 may be increased before compared with after cavity sealing (very low certainty).
1 finding from 1 review
MMP-9 expression/activity · Human carious dentin
No difference in MMP-9 expression/activity was found before versus after cavity sealing (very low certainty).
1 finding from 1 review
Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
1 finding from 1 review
Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18…
2 studies · 25 participants
GRADE not reported
Bacterial collagenolytic enzymatic activity · Human ex vivo carious lesions / caries-associated biofilm
Bacterial collagenolytic enzymatic activity in caries biofilm is inconclusive across two small studies (ungraded; GRADE not feasible).
1 finding from 1 review
Results are inconclusive: protein-degrading bacteria isolated from root caries biofilm were capable of degrading collagen (Prevotella, Actinobaculum, Propionibacterium predominant; proportion 7% in root caries)…
2 studies · 9 participants
GRADE not reported
MMP-2 expression/activity · Human carious dentin
No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).
1 finding from 1 review
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Stepwise excavation reduced the reported risk of pulp exposure by 69% versus complete caries removal (RR 0.31; ungraded).
1 finding from 1 review
RR 0.31 [0.17, 0.57]
262 participants
GRADE not reported
Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth
A second meta-analysis reported odds ratios of 2.44 to 3.63 favouring 38% SDF over fluoride varnish/water for caries arrest (ungraded).
2 findings from 1 review
OR (caries arrest) OR 2.44-3.63 (range); 2.44 = Chu estimate including 30% SDF
3 studies
GRADE not reported
Proportion (caries arrest) 81 [68, 89]
12 studies
GRADE not reported
Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth
Twice-yearly 38% SDF was reported to arrest more caries than once-yearly application (24-month rates 91% vs 79%; ungraded).
1 finding from 1 review
Adverse events (any type) and safety of sealant · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
The review found no eligible studies for this question.
1 finding from 1 review
Subjective evaluation of the treatments by participants · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
The review found no eligible studies for this question.
1 finding from 1 review
Efficiency, costs or cost-effectiveness · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review
Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether hall Technique (sealing with a preformed metal crown) changes failure of therapy compared with non-restorative cavity control (NRCC) (very low certainty).
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether sealing using sealant materials changes failure of therapy compared with no treatment (very low certainty).
1 finding from 1 review
Pulp exposure during caries removal · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth
Partial caries removal (single stage; residual dentinal caries… probably leads to lower pulp exposure during caries removal compared with complete caries removal (moderate certainty).
1 finding from 1 review
Restoration failure · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth
It is very uncertain whether partial caries removal (single stage; residual dentinal caries… changes failure of restorations compared with complete caries removal (very low certainty).
1 finding from 1 review