Findings

What do systematic reviews say?

102 questions · 102 findings · 13 reviews

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No studies found 15 · 14.7%GRADE not reported 4 · 3.9%Very low 14 · 13.7%Low 34 · 33.3%Moderate 34 · 33.3%High 1 · 1%

Angiotensin‐converting enzyme inhibitors vs calcium channel blockers

Haemoglobin (g/dL) · kidney transplant recipients

1 finding from 1 review

Antihypertensive treatment for kidney transplant recipients 2009 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 332 participants
Moderate

Angiotensin‐converting enzyme inhibitors vs calcium channel blockers

Blood loss: post‐treatment haematocrit (%) · kidney transplant recipients

1 finding from 1 review

Antihypertensive treatment for kidney transplant recipients 2009 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 153 participants
Moderate

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Cardiac T2* value · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 191 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

MIC · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 138 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

LVEF (echocardiography) · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 136 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Ferritin (µg/L) · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 187 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Liver T2* value · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 127 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

LIC · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Moderate

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Adverse events · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 234 participants
Very low

CCBs vs diuretics

All‐cause mortality · patients with hypertension

CCBs showed no clear difference in all‐cause mortality compared with diuretic (moderate certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.98 [0.92, 1.04]
5 studies · 35057 participants
Moderate

CCBs vs beta‐blocker

Cardiovascular mortality · patients with hypertension

CCBs may leads to lower cardiovascular mortality compared with β‐blocker (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.9 [0.81, 0.99]
4 studies · 44825 participants
Low

CCBs vs ACE inhibitor

All‐cause mortality · patients with hypertension

CCBs showed no clear difference in all‐cause mortality compared with ACE inhibitor (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.97 [0.91, 1.03]
7 studies · 27999 participants
Low

CCBs vs ACE inhibitor

Myocardial infarction · patients with hypertension

CCBs showed no clear difference in myocardial infarction compared with ACE inhibitor (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 1.05 [0.97, 1.14]
7 studies · 27999 participants
Low

CCBs vs ACE inhibitor

Stroke · patients with hypertension

CCBs may leads to lower stroke compared with ACE inhibitor (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.9 [0.81, 0.99]
7 studies · 27999 participants
Low

CCBs vs ACE inhibitor

Congestive heart failure · patients with hypertension

CCBs may leads to higher congestive heart failure compared with ACE inhibitor (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 1.16 [1.06, 1.28]
5 studies · 25276 participants
Low

CCBs vs ACE inhibitor

Cardiovascular mortality · patients with hypertension

CCBs showed no clear difference in cardiovascular mortality compared with ACE inhibitor (moderate certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.98 [0.89, 1.07]
6 studies · 27619 participants
Moderate

CCBs vs ARB

All‐cause mortality · patients with hypertension

CCBs showed no clear difference in all‐cause mortality compared with ARB (moderate certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 1 [0.92, 1.08]
6 studies · 25611 participants
Moderate

CCBs vs ARB

Myocardial infarction · patients with hypertension

CCBs probably leads to lower myocardial infarction compared with ARB (moderate certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.82 [0.72, 0.94]
6 studies · 25611 participants
Moderate

CCBs vs ARB

Stroke · patients with hypertension

CCBs showed no clear difference in stroke compared with ARB (moderate certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 0.89 [0.76, 1]
6 studies · 25611 participants
Moderate

CCBs vs ARB

Congestive heart failure · patients with hypertension

CCBs may leads to higher congestive heart failure compared with ARB (low certainty).

1 finding from 1 review

Calcium channel blockers versus other classes of drugs for hypertension 2022 · Cochrane Headline outcomes only
RR 1.2 [1.06, 1.36]
5 studies · 23265 participants
Low