Cochrane · systematic review · CD003598
Antihypertensive treatment for kidney transplant recipients
Cross, NB, Webster, AC, Masson, P, et al. · Cochrane Database of Systematic Reviews · 2009 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
21
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 14.3%Low 11 · 52.4%Moderate 7 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Calcium channel blockers versus placebo/no treatment for kidney transplant recipients
Population: kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death Calcium channel blockers vs placebo/no treatment | RR 0.82 [0.37, 1.82] | 12 studies · 792 participants | Low Downgraded: risk of bias, imprecision |
Graft loss Calcium channel blockers vs placebo/no treatment | RR 0.75 [0.57, 0.99] | 17 studies · 1255 participants | Low Downgraded: risk of bias |
GFR (measured or estimated) mL/min Calcium channel blockers vs placebo/no treatment | no estimate extracted | 18 studies · 1119 participants | Moderate Downgraded: risk of bias |
Acute rejection Calcium channel blockers vs placebo/no treatment | RR 1.02 [0.85, 1.23] | 11 studies · 771 participants | Low Downgraded: risk of bias |
Withdrawal due to side effects Calcium channel blockers vs placebo/no treatment | RR 0.99 [0.53, 1.87] | 2 studies · 156 participants | Low Downgraded: risk of bias |
Proteinuria g/24 h Calcium channel blockers vs placebo/no treatment | no estimate extracted | 2 studies · 90 participants | Low Downgraded: risk of bias |
Blood pressure mm Hg Calcium channel blockers vs placebo/no treatment | no estimate extracted | 10 studies · 590 participants | Very low Downgraded: risk of bias, inconsistency |
ACE inhibitors versus placebo/no treatment for kidney transplant recipients
Population: kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ACE inhibitors vs placebo/no treatment | RR 1 [0.07, 14.55] | 1 study · 30 participants | Low Downgraded: risk of bias |
Graft loss ACE inhibitors vs placebo/no treatment | no estimate extracted | 2 studies · 93 participants | Low Downgraded: risk of bias, inconsistency |
GFR (measured or estimated) mL/min ACE inhibitors vs placebo/no treatment | no estimate extracted | 3 studies · 77 participants | Low Downgraded: risk of bias |
Proteinuria g/24 h ACE inhibitors vs placebo/no treatment | no estimate extracted | 3 studies · 175 participants | Moderate |
Serum creatinine umol/L ACE inhibitors vs placebo/no treatment | no estimate extracted | 7 studies · 272 participants | Low Downgraded: risk of bias |
Haemoglobin g/L ACE inhibitors vs placebo/no treatment | no estimate extracted | 5 studies · 191 participants | Moderate Downgraded: risk of bias |
Blood pressure mmHg ACE inhibitors vs placebo/no treatment | no estimate extracted | 9 studies · 392 participants | Very low Downgraded: risk of bias, inconsistency |
ACE Inhibitors versus calcium channel blockers for kidney transplant recipients
Population: kidney transplant recipients
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ACE Inhibitors vs calcium channel blockers | RR 4.03 [0.45, 35.82] | 2 studies · 221 participants | Low Downgraded: risk of bias |
Graft loss ACE Inhibitors vs calcium channel blockers | RR 7.37 [0.39, 140.35] | 1 study · 152 participants | Low Downgraded: risk of bias |
GFR (measured or estimated) ACE Inhibitors vs calcium channel blockers | no estimate extracted | 6 studies · 296 participants | Moderate Downgraded: risk of bias |
Acute rejection ACE Inhibitors vs calcium channel blockers | RR 1.54 [1.14, 2.07] | 2 studies · 221 participants | Very low Downgraded: risk of bias |
Proteinuria g/24 h ACE Inhibitors vs calcium channel blockers | no estimate extracted | 2 studies · 142 participants | Moderate Downgraded: risk of bias |
Haemoglobin g/L ACE Inhibitors vs calcium channel blockers | no estimate extracted | 5 studies · 332 participants | Moderate Downgraded: risk of bias |
Haematocrit % ACE Inhibitors vs calcium channel blockers | no estimate extracted | 4 studies · 153 participants | Moderate Downgraded: risk of bias |