Findings

What do systematic reviews say?

92 questions · 92 findings · 7 reviews · Kidney and Transplant

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No studies found 20 · 21.7%GRADE not reported 3 · 3.3%Very low 33 · 35.9%Low 29 · 31.5%Moderate 7 · 7.6%High 0 · 0%

Aldosterone antagonists vs calcium channel blockers

Death · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

Cardiovascular events · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

Doubling serum creatinine · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

AKI · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

Proteinuria · proteinuric CKD

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Aldosterone antagonists vs calcium channel blockers

eGFR · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Sevelamer vs calcium

Death (all causes) · people with CKD

Summary of findings: Sevelamer may leads to lower death (all causes) compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.53 [0.3, 0.91]
16 studies · 3688 participants
Low

Summary of findings: Sevelamer vs calcium

Cardiovascular mortality · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes cardiovascular death compared with calcium (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.45 [0.11, 1.77]
6 studies · 2829 participants
Very low

Summary of findings: Sevelamer vs calcium

Hypercalcaemia · people with CKD

It is very uncertain whether summary of findings: Sevelamer changes hypercalcaemia compared with calcium (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.3 [0.2, 0.43]
19 studies · 4084 participants
Very low

Summary of findings: Sevelamer vs calcium

Nausea · people with CKD

Summary of findings: Sevelamer showed no clear difference in nausea compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.98 [0.56, 1.71]
4 studies · 365 participants
Low

Summary of findings: Sevelamer vs calcium

Vomiting · people with CKD

Summary of findings: Sevelamer showed no clear difference in vomiting compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.95 [0.54, 1.69]
2 studies · 263 participants
Low

Summary of findings: Sevelamer vs calcium

Constipation · people with CKD

Summary of findings: Sevelamer showed no clear difference in constipation compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 1.35 [0.71, 2.57]
6 studies · 2652 participants
Low

Summary of findings: Sevelamer vs calcium

Serum phosphate level · people with CKD

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
23 studies · 4360 participants
Very low

Summary of findings ‐ Lanthanum vs calcium

Death (all causes) · people with CKD

Summary of findings ‐ Lanthanum showed no clear difference in death (all causes) compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.76 [0.18, 3.11]
6 studies · 505 participants
Low

Summary of findings ‐ Lanthanum vs calcium

Cardiovascular mortality · people with CKD

The review found no eligible studies for this question.

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Lanthanum vs calcium

Hypercalcaemia · people with CKD

Summary of findings ‐ Lanthanum may leads to lower hypercalcaemia compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.16 [0.06, 0.43]
8 studies · 1347 participants
Low

Summary of findings ‐ Lanthanum vs calcium

Nausea · people with CKD

Summary of findings ‐ Lanthanum showed no clear difference in nausea compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 1.65 [0.95, 2.89]
5 studies · 1191 participants
Low

Summary of findings ‐ Lanthanum vs calcium

Vomiting · people with CKD

It is very uncertain whether summary of findings ‐ Lanthanum changes vomiting compared with calcium (very low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 3.88 [0.48, 31.7]
2 studies · 1058 participants
Very low

Summary of findings ‐ Lanthanum vs calcium

Constipation · people with CKD

Summary of findings ‐ Lanthanum showed no clear difference in constipation compared with calcium (low certainty).

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
RR 0.79 [0.5, 1.26]
5 studies · 1213 participants
Low

Summary of findings ‐ Lanthanum vs calcium

Serum phosphate level · people with CKD

1 finding from 1 review

Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) 2018 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 400 participants
Very low