Findings

What do systematic reviews say?

69 questions · 72 findings · 6 reviews · Common Mental Disorders

No studies found 0 · 0%GRADE not reported 6 · 8.3%Very low 20 · 27.8%Low 32 · 44.4%Moderate 11 · 15.3%High 3 · 4.2%

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.11 [0.74, 1.65]
2 studies · 991 participants
Low

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.05 [0.91, 1.21]
2 studies · 991 participants
High

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 945 participants
High

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse effects compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.86 [0.49, 7.05]
2 studies · 991 participants
Low

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with naSSAs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.5 [0.29, 7.73]
1 study · 30 participants
Low

Failure to remit at endpoint · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse events compared with naSSAs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.5 [0.29, 7.73]
1 study · 30 participants
Low