Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

135 questions · 141 findings · 17 reviews · Skin

No studies found 17 · 12.1%GRADE not reported 14 · 9.9%Very low 14 · 9.9%Low 54 · 38.3%Moderate 30 · 21.3%High 12 · 8.5%

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Assessment of erythema or telangiectasia · Participants with rosacea

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Ketoconazole vs placebo

Failure to achieve complete resolution Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole may leads to lower failure to achieve complete resolution Clinical assessment compared with placebo (low certainty).

1 finding from 1 review

Ketoconazole vs steroids

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (combined for face and scalp)… compared with steroids (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution ‐ Face only Clinical assessment compared with ciclopirox (low certainty).

1 finding from 1 review

Ketoconazole vs ciclopirox

Failure to achieve complete resolution (long term) ‐ Face only Clinical assessment · patients with seborrhoeic dermatitis

Ketoconazole showed no clear difference in failure to achieve complete resolution (long term) ‐ Face only… compared with ciclopirox (low certainty).

1 finding from 1 review

Ciclopirox vs placebo

Failure to achieve complete resolution (combined for face and scalp) Clinical assessment · patients with seborrhoeic dermatitis

Ciclopirox probably leads to lower failure to achieve complete resolution (combined for face and scalp)… compared with placebo (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.1% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

3 findings from 1 review

Tacrolimus 0.03% vs corticosteroids

Physician's assessment of global response of improvement, clear or excellent ‐ 6 weeks · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher physician's assessment of global response of improvement, clear or… compared with corticosteroids (moderate certainty).

4 findings from 1 review
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Tacrolimus 0.03% vs corticosteroids

Participant's self‐assessment of global response of improvement: tacrolimus 0.03% 2x/day versus hydrocortisone acetate 1% 2x/day · people with atopic dermatitis

Tacrolimus 0.03% probably leads to higher participant's self‐assessment of global response of improvement:… compared with corticosteroids (moderate certainty).

1 finding from 1 review

Tacrolimus 0.03% vs Topical tacrolimus

Physician's assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.03% leads to lower physician's assessment of global response of improvement, clear or… compared with tacrolimus 0.1% (high certainty).

1 finding from 1 review

Tacrolimus 0.03% vs pimecrolimus 1%

Physician's assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.03% may leads to higher physician's assessment of global response of improvement compared with pimecrolimus 1% (low certainty).

1 finding from 1 review

Tacrolimus 0.1% vs corticosteroids

Participant's self‐assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.1% may leads to higher participant's self‐assessment of global response of improvement compared with corticosteroids (low certainty).

1 finding from 1 review