Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

106 questions · 122 findings · 17 reviews

No studies found 23 · 18.9%GRADE not reported 5 · 4.1%Very low 28 · 23%Low 37 · 30.3%Moderate 28 · 23%High 1 · 0.8%

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Difficulty in mouth opening (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) led to lower difficulty in mouth opening (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Antioxidants (lycopene, curcumin, Oxitard) led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

The proportion of pressure ulcers healed · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes pressure ulcers healed compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Time to complete healing of pressure ulcers ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Acceptability of nutritional supplements ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes side effects: at least one adverse gastrointestinal event compared with standard diet or placebo (very low certainty).

1 finding from 1 review