Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (maxillary teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (maxillary teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review

High-viscosity glass-ionomer ART restorations vs Conventional treatment using composite (with local anaesthetic)

Pain (primary dentition) · Children with carious primary teeth

ART using H-GIC showed no clear difference in pain (primary dentition) compared with conventional treatment using composite (with local anaesthetic); GRADE not reported.

1 finding from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Caries in primary teeth: dmft (3 years) · Pregnant women (for preventing dental caries in the primary teeth of their children)

The review found no eligible studies for this question.

1 finding from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Marginal bone level (first bone to implant contact, FBIC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant-supported single crowns (zirconia veneered with… showed no clear difference in marginal bone level (first bone to implant contact, FBIC) compared with metal-ceramic implant-supported single crowns; GRADE not reported.

4 findings from 1 review
Show 1 more finding

ART using glass ionomer cement (GIC) vs Amalgam restoration

Restoration failure (primary dentition) · Children and adolescents with dental caries (primary teeth and permanent immature teeth)

ART using glass ionomer cement (GIC) showed no clear difference in restoration failure (primary teeth) compared with conventional treatment using amalgam; GRADE not reported.

1 finding from 1 review

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

Caries on occlusal surfaces of permanent molars (12 months) · Children and adolescents (general population, aged under 20 years)

Resin-based fissure sealant (2nd/3rd/4th generation) led to lower caries on occlusal surfaces of permanent molars (36 months) compared with no sealant (control/no treatment); GRADE not reported.

3 findings from 1 review

Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)

Aesthetics · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
  • No comparative data were presented with regard to aesthetics. Aesthetics evaluated by the patient was reported dichotomously (yes/no) in the trial but no between-group estimate was presented.
    1 study
    GRADE not reported

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Periodontal or peri-implant status: gingival recession (REC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

Metal-free implant abutments (zirconia) showed no clear difference in gingival/mucosal recession (REC) compared with metal implant abutments (titanium); GRADE not reported.

1 finding from 1 review

Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
  • No comparative data were presented for the pre-specified secondary outcomes. The trial analyzed and reported plaque index, bleeding on probing and pocket probing depth but no between-group estimate was presented in the…
    1 study
    GRADE not reported

Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)

Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

It is very uncertain whether metal-free implant abutments (zirconia) changes abutment failure compared with metal implant abutments (titanium) (very low certainty).

1 finding from 1 review

Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs

Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)

The review found no eligible studies for this question.

1 finding from 1 review
  • No data were presented for any of the pre-specified secondary outcomes. The trial registered pocket depth, bleeding on probing and mobility at follow-up visits but did not report the data.
    0 studies
    No studies found

Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs

Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis

It is very uncertain whether metal-free cantilevered FDPs (feldspathic-veneered zirconia) changes cantilevered bridge complications compared with metal-ceramic cantilevered FDPs (very low certainty).

2 findings from 1 review

Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown

It is very uncertain whether metal-free implant-supported single crowns (zirconia veneered with… changes aesthetic evaluation (patient satisfaction VAS) compared with metal-ceramic implant-supported single crowns (very low certainty).

2 findings from 1 review

Metal-free single crowns (full-contour zirconia) vs Cast gold (conventional metal) single crowns

Crown complications · Adults (18 years or older) needing a single crown in the molar or premolar region

It is very uncertain whether metal-free single crowns (full-contour zirconia) changes crown complications compared with cast gold (conventional metal) single crowns (very low certainty).

2 findings from 1 review

Fluoride supplementation (tablets, drops, lozenges or chewing gum) vs placebo or no treatment

Fluorosis (mandibular teeth) at 5 years · Pregnant women (for preventing dental caries in the primary teeth of their children)

It is very uncertain whether fluoride supplementation (tablets, drops, lozenges or chewing gum) changes fluorosis (mandibular teeth) at 5 years compared with placebo or no treatment (very low certainty).

1 finding from 1 review