What do systematic reviews say?

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

It is very uncertain whether interventions (vitamin B1, mefenamic acid, tranexamic acid) changes side effects: gastrointestinal disturbances (diarrhoea, lower… compared with placebo or active comparators (desmopressin, sodium diclofenac,… (very low certainty).

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  OR 4.69 [1.2, 18.44]
  1 study · 38 participants
  Very low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low
• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 24 participants
  Very low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low
• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 110 participants
  Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low
• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 290 participants
  Very low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Interventions (vitamin B1, mefenamic acid, tranexamic acid) showed no clear difference in side effects: headache compared with placebo or active comparators (desmopressin, sodium diclofenac,… (low certainty).

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  OR 0.58 [0.18, 1.92]
  1 study · 100 participants
  Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

Interventions (vitamin B1, mefenamic acid, tranexamic acid) showed no clear difference in side effects: vomiting compared with placebo or active comparators (desmopressin, sodium diclofenac,… (low certainty).

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  OR 0.74 [0.25, 2.18]
  1 study · 100 participants
  Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 participants
  GRADE not reported

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 110 participants
  Low
• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 152 participants
  Low

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

The review found no eligible studies for this question.

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interventions (vitamin B1, mefenamic acid, tranexamic acid) vs placebo or active comparators (desmopressin, sodium diclofenac, flavonoids)

• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 94 participants
  Low
• Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine‐device use 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 38 participants
  Very low

Primary health professional‐led psychological interventions vs usual care or no treatment

The review found no eligible studies for this question.

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Primary health professional‐led psychological interventions vs usual care or no treatment

The review found no eligible studies for this question.

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Primary health professional‐led psychological interventions vs usual care or no treatment

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1572 participants
  Very low

Primary health professional‐led psychological interventions vs usual care or no treatment

It is very uncertain whether primary health professional‐led psychological interventions changes adverse events (RR > 1 denotes greater risk of harm) compared with usual or no care (very low certainty).

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  RR 2.22 [0.23, 21.34]
  4 studies · 1242 participants
  Very low

Mindfulness‐based interventions (MBIs) vs no treatment

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 112 participants
  Very low
• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 112 participants
  Very low

Mindfulness‐based interventions (MBIs) vs other treatments

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 286 participants
  Very low
• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 286 participants
  Very low

Mindfulness‐based interventions (MBIs) vs other treatments

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 523 participants
  Low
• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 409 participants
  Low

Mindfulness‐based interventions (MBIs) vs other treatments

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low

Mindfulness‐based interventions (MBIs) vs other treatments

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 971 participants
  Very low
• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 415 participants
  Very low

Mindfulness‐based interventions (MBIs) vs other treatments

• Mindfulness‐based interventions for substance use disorders 2021 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 1531 participants
  High