What do systematic reviews say?

Imiquimod vs placebo

Summary of findings for imiquimod probably leads to higher response to treatment at 12 months ‐ overall response compared with placebo (moderate certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 9.1 [2.38, 34.77]
  1 study · 47 participants
  Moderate

Imiquimod vs placebo

Summary of findings for imiquimod showed no clear difference in progression to vulval cancer at 12 months compared with placebo (low certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 0.48 [0.05, 4.93]
  1 study · 47 participants
  Low

Imiquimod vs placebo

Summary of findings for imiquimod leads to lower HPV DNA persistence compared with placebo (high certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 0.43 [0.26, 0.72]
  1 study · 47 participants
  High

Imiquimod vs placebo

Summary of findings for imiquimod leads to higher pain ‐ any grade compared with placebo (high certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 3.43 [1.8, 6.52]
  1 study · 52 participants
  High

Imiquimod vs placebo

Summary of findings for imiquimod leads to higher dose reductions compared with placebo (high certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 7.77 [1.61, 37.36]
  2 studies · 83 participants
  High

Imiquimod vs cidofovir

Summary of findings for imiquimod showed no clear difference in response to treatment at 6 months ‐ overall response compared with cidofovir (moderate certainty).

• Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.73, 1.18]
  1 study · 180 participants
  Moderate

Imiquimod vs placebo

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Imiquimod vs placebo

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Imiquimod vs cidofovir

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Imiquimod vs cidofovir

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Imiquimod vs cidofovir

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Imiquimod vs cidofovir

The review found no eligible studies for this question.

• Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: intervention vs no treatment

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  27 studies · 3423 participants
  Moderate
• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 540 participants
  Moderate

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 260 participants
  Moderate
• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 967 participants
  Moderate

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 160 participants
  Low

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 246 participants
  Moderate
• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  14 studies · 1126 participants
  High

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 214 participants
  Moderate

Summary of findings: intervention vs usual care or attention control

• Physical rehabilitation approaches for the recovery of function and mobility following stroke 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Low