Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,155 questions · 1,191 findings · 195 reviews · Headline outcomes only

No studies found 209 · 17.5%GRADE not reported 51 · 4.3%Very low 256 · 21.5%Low 273 · 22.9%Moderate 284 · 23.8%High 118 · 9.9%

Intervention not reported

Dupilumab (4 RCTs; 990 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes dupilumab (4 RCTs; 990 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (3 RCTs; 74 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (3 RCTs; 74 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 2680 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

CIM331 (1 RCT; 27 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in CIM331 (1 RCT; 27 participants) (low certainty).

1 finding from 1 review

Intervention not reported

GBR830 (1 RCT; 46 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in GBR830 (1 RCT; 46 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Azathiopine (AZA) (1 RCT; 41 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in azathiopine (AZA) (1 RCT; 41 participants) (low certainty).

1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QAW039 (1 RCT; 76 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CsAI (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes csAI (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 17 RCTsTotal participants: 3972 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

The intervention probably leads to lower QAW039 (1 RCT; 76 participants) (moderate certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (9 RCTs; 1663 participants) · patients with moderate to severe eczema

The intervention may leads to lower dupilumab (9 RCTs; 1663 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Clinical Global (CIBIC+) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 2797 participants
    High

Intervention not reported

Clinical Global: (CIBIC+) · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 757 participants
    Moderate

Intervention not reported

Cognitive function: ADAS‐Cog 70‐point scale · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 569 participants
    Moderate