Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Intensive counseling vs usual family planning care

Continuation of hormonal contraceptive method · Women of reproductive age seeking to avoid pregnancy

It is very uncertain whether intensive counseling changes continuation of hormonal contraceptive method compared with usual family planning care (very low certainty).

1 finding from 1 review

Reminders (+/‐ educational information) vs usual family planning care

Continuation of hormonal contraceptive method · Women of reproductive age seeking to avoid pregnancy

It is very uncertain whether reminders (+/‐ educational information) changes continuation of hormonal contraceptive method compared with usual family planning care (very low certainty).

1 finding from 1 review

Reminders (+/‐ educational information) vs usual family planning care

Adherence to method use as indicated by on‐time injections overall · Women of reproductive age seeking to avoid pregnancy

Reminders (+/‐ educational information) showed no clear difference in adherence to method use as indicated by on‐time injections overall compared with usual family planning care (low certainty).

1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to serious adverse events (non‐comparative cohort studies) Measured by: proportion of participants withdrawn from treatment Average study duration (range): 7.9 months (1 month to 37 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to adverse events of unknown severity Measured by: proportion of participants withdrawn from treatment Average study duration (range): 4.6 months (21 days to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to non‐serious adverse events Measured by: proportion of participants withdrawn from treatment Average study duration (range): 5.60 months (0.6 months to 41 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate for unknown reasons Measure by: proportion of participants withdrawn from treatment Average study duration (range): 6.13 months (1 day to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review