Findings

What do systematic reviews say?

4,410 questions · 8,901 findings · 1,091 reviews

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No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Breast massage and low frequency pulse treatment vs usual care

Breast pain · postpartum breastfeeding women

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing mastitis after childbirth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Breast massage and low frequency pulse treatment vs usual care

Number of women with adverse events · postpartum breastfeeding women

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing mastitis after childbirth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Voiding education with uroflowmetry and feedback vs anticholinergics

Resolution of daytime urinary incontinence · children aged 6 to 12 years with overactive bladder with urge incontinence

It is very uncertain whether voiding education with uroflowmetry and feedback changes resolution of daytime urinary incontinence at 12 months after 6… compared with anticholinergics (very low certainty).

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
RR 1.02 [0.58, 1.78]
1 study · 64 participants
Very low

Voiding education with uroflowmetry and feedback vs anticholinergics

Frequency of incontinence episodes · children aged 6 to 12 years with overactive bladder with urge incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Voiding education with uroflowmetry and feedback vs anticholinergics

Objective measurement of volume of incontinent episodes · children aged 6 to 12 years with overactive bladder with urge incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Voiding education with uroflowmetry and feedback vs anticholinergics

Resource implications (e.g. cost of incontinence management methods) · children aged 6 to 12 years with overactive bladder with urge incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Voiding education with uroflowmetry and feedback vs anticholinergics

Quality of life measurements · children aged 6 to 12 years with overactive bladder with urge incontinence

The review found no eligible studies for this question.

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Voiding education with uroflowmetry and feedback vs anticholinergics

Adverse effects · children aged 6 to 12 years with overactive bladder with urge incontinence

1 finding from 1 review

Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 64 participants
GRADE not reported

Fluoride toothpaste 440 ppm (lower concentration) vs 1450 to 1500 ppm F toothpaste

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride toothpaste 440 ppm (lower concentration) probably leads to lower fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1450 ppm (higher concentration) (moderate certainty).

1 finding from 1 review

Topical fluoride as a cause of dental fluorosis in children 2024 · Cochrane All outcomes
Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)
RR 0.72 [0.58, 0.89]
1 study · 1009 participants
Moderate

Fluoride toothpaste 550 ppm (lower concentration) vs Fluoride toothpaste 1000 ppm or more (higher concentration)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

Fluoride toothpaste 550 ppm (lower concentration) probably leads to lower fluorosis (percentage prevalence in permanent teeth) compared with fluoride toothpaste 1000 ppm (higher concentration) (moderate certainty).

1 finding from 1 review

Topical fluoride as a cause of dental fluorosis in children 2024 · Cochrane All outcomes
Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)
RR 0.75 [0.57, 0.99]
1 study · 959 participants
Moderate

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Adverse events (grade ≥ 3) · newly‐diagnosed EOC

Chemotherapy with TKI followed by TKI maintenance probably leads to higher any adverse event grade ≥ 3 compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
RR 1.31 [1.11, 1.55]
1 study · 188 participants
Moderate

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Hypertension grade ≥ 3 · newly‐diagnosed EOC

Chemotherapy with TKI followed by TKI maintenance may leads to higher hypertension grade ≥ 3 compared with chemotherapy alone (low certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
RR 6.49 [2.02, 20.87]
1 study · 1352 participants
Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Bowel fistula / perforation (grade ≥ 3) · newly‐diagnosed EOC

The review found no eligible studies for this question.

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Overall survival (OS) · platinum‐sensitive recurrent EOC

Chemotherapy with TKI followed by TKI maintenance showed no clear difference in overall survival (OS) compared with chemotherapy alone (low certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
HR 0.86 [0.67, 1.11]
1 study · 282 participants
Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Progression‐free survival · platinum‐sensitive recurrent EOC

Chemotherapy with TKI followed by TKI maintenance probably leads to lower progression‐free survival (PFS) compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
HR 0.56 [0.44, 0.72]
1 study · 282 participants
Moderate

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

QoL · platinum‐sensitive recurrent EOC

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Adverse events (grade ≥ 3) · platinum‐sensitive recurrent EOC

The review found no eligible studies for this question.

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Hypertension (grade ≥ 2) · platinum‐sensitive recurrent EOC

The review found no eligible studies for this question.

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Bowel fistula / perforation (grade ≥ 3) · platinum‐sensitive recurrent EOC

The review found no eligible studies for this question.

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Chemotherapy with TKI followed by TKI maintenance vs chemotherapy alone

Overall survival (OS) · newly‐diagnosed EOC

Chemotherapy with TKI followed by TKI maintenance showed no clear difference in overall survival (OS) compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer 2023 · Cochrane Headline outcomes only
HR 0.99 [0.84, 1.17]
2 studies · 1451 participants
Moderate