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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,206 questions in 117 reviews · Common Mental Disorders
current versionsNo studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Paroxetine vs bupropion Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.16 [0.62, 2.2] | 2 studies · 240 participants | Moderate |
Paroxetine vs bupropion Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.6 [0.43, 5.92] | 1 study · 140 participants | Moderate |
Paroxetine vs citalopram Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.54 [1.04, 2.28] | 1 study · 406 participants | Moderate |
Paroxetine vs citalopram Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs citalopram Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs citalopram Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | NR | No studies |
Paroxetine vs older ADs Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.23 [0.49, 3.07] | 3 studies · 401 participants | Low |
Paroxetine vs citalopram SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 201 participants | Moderate |
Paroxetine vs citalopram Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.99 [0.61, 1.6] | 1 study · 406 participants | Moderate |
Paroxetine vs citalopram Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.74 [0.46, 1.21] | 1 study · 406 participants | Moderate |
Paroxetine vs duloxetine Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.89 [0.7, 1.14] | 6 studies · 1821 participants | Moderate |
Paroxetine vs duloxetine Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs duloxetine Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs duloxetine Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.98 [0.8, 1.19] | 6 studies · 1821 participants | Moderate |
Paroxetine vs duloxetine SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 6 studies · 1481 participants | Moderate |
Paroxetine vs duloxetine Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.97 [0.77, 1.23] | 6 studies · 1821 participants | Moderate |
Paroxetine vs duloxetine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.81 [0.64, 1.01] | 6 studies · 1870 participants | Moderate |
Paroxetine vs older ADs SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 35 studies · 4745 participants | Moderate |
Paroxetine vs escitalopram Failure to respond at endpoint (6‐12 weeks) · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.12 [0.76, 1.65] | 2 studies · 784 participants | Moderate |
Paroxetine vs escitalopram Failure to respond at 1‐4 weeks · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs escitalopram Failure to respond at 16‐24 weeks · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.36 [0.87, 2.12] | 1 study · 459 participants | Moderate |
Paroxetine vs escitalopram Failure to remit at endpoint · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.15 [0.6, 2.22] | 2 studies · 784 participants | Low |
Paroxetine vs escitalopram SMD at endpoint · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 2 studies · 772 participants | Low |
Paroxetine vs escitalopram Failure to complete ‐ any cause ‐ · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.47 [0.77, 2.79] | 2 studies · 784 participants | Moderate |
Paroxetine vs escitalopram Participants with at least some Side Effects · depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.28 [0.86, 1.91] | 1 study · 454 participants | Moderate |
Paroxetine vs fluoxetine Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.98 [0.79, 1.23] | 11 studies · 2418 participants | Moderate |
Paroxetine vs fluoxetine Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs fluoxetine Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs older ADs Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.84 [0.73, 0.96] | 44 studies · 6810 participants | Moderate |
Paroxetine vs fluoxetine Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs fluoxetine SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 9 studies · 2109 participants | Moderate |
Paroxetine vs fluoxetine Failure to complete ‐ any cause ‐ total drop out rate · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.05 [0.89, 1.23] | 13 studies · 2798 participants | Moderate |
Paroxetine vs fluoxetine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.94 [0.69, 1.28] | 9 studies · 2255 participants | Moderate |
Paroxetine vs fluvoxamine Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.19 [0.72, 1.94] | 3 studies · 261 participants | Moderate |
Paroxetine vs fluvoxamine Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.71 [0.41, 1.24] | 3 studies · 281 participants | Moderate |
Paroxetine vs fluvoxamine Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs fluvoxamine Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.78 [0.44, 1.38] | 3 studies · 261 participants | Moderate |
Paroxetine vs fluvoxamine SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 58 participants | Moderate |
Paroxetine vs fluvoxamine Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.96 [0.54, 1.72] | 3 studies · 261 participants | Moderate |
Paroxetine vs older ADs Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.64 [0.54, 0.77] | 42 studies · 6132 participants | Moderate |
Paroxetine vs fluvoxamine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.12 [0.42, 2.97] | 3 studies · 261 participants | Moderate |
Paroxetine vs hypericum Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.6 [0.95, 2.69] | 1 study · 251 participants | Moderate |
Paroxetine vs hypericum Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs hypericum Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs hypericum Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.84 [1.11, 3.06] | 1 study · 251 participants | Moderate |
Paroxetine vs hypericum SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 244 participants | Moderate |
Paroxetine vs hypericum Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.9 [0.98, 3.67] | 1 study · 251 participants | Moderate |
Paroxetine vs hypericum Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 2.6 [1.51, 4.46] | 1 study · 251 participants | Moderate |
Paroxetine vs milnacipran Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.93 [0.59, 1.47] | 1 study · 302 participants | Moderate |
Paroxetine vs milnacipran Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |