Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Acyclovir + calamine + cetirizine vs calamine + cetirizine

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Headache. · pityriasis rosea

Acyclovir + calamine + cetirizine showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

Acyclovir showed no clear difference in the proportion of participants with resolution of itch within 2… compared with erythromycin (low certainty).

1 finding from 1 review

Acyclovir vs erythromycin

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Acyclovir vs erythromycin

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea
1 finding from 1 review

Clarithromycin vs placebo

Reduction in itch score within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Clarithromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by a medical practitioner · pityriasis rosea

Clarithromycin showed no clear difference in the proportion of participants with good or excellent rash… compared with placebo (moderate certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Erythromycin vs placebo

The proportion of participants with good or excellent rash improvement within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Erythromycin vs placebo

The proportion of participants with resolution of itch within 2 weeks, as rated by the participant · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Severe skin drug‐induced rash · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Long‐term sequelae · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Hospitalisation for drug‐induced skin reaction · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

SJS/TEN (Stevens‐Johnson syndrome/toxic epidermal necrolysis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

AGEP (acute generalised exanthematous pustulosis) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

HSS (hypersensitivity) reaction including SJS/TEN (clinically diagnosed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The intervention probably leads to lower HSS (hypersensitivity) reaction including SJS/TEN (clinically… (moderate certainty).

1 finding from 1 review

Intervention not reported

HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks clinical assessment) · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The intervention probably leads to lower HSS reaction including SJS/TEN (immunologically confirmed) (6 weeks… (moderate certainty).

1 finding from 1 review