Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

749 questions · 769 findings · 63 reviews · Headline outcomes only

No studies found 202 · 26.3%GRADE not reported 31 · 4%Very low 172 · 22.4%Low 211 · 27.4%Moderate 106 · 13.8%High 47 · 6.1%

Lidocaine vs aprindine

Specific behaviour ‐ agitation · patients with myocardial infarction

It is very uncertain whether lidocaine changes agitation compared with aprindine (very low certainty).

1 finding from 1 review

Lidocaine vs pirmenol

Adverse events (any type) and safety of sealant · patients with myocardial infarction

It is very uncertain whether lidocaine changes safety (AEs; adverse drug reaction): any adverse event compared with pirmenol (very low certainty).

1 finding from 1 review

Lidocaine vs placebo or no intervention

Adverse events (AEs; adverse drug reaction): sinus bradycardia · patients with acute myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): sinus bradycardia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Lidocaine vs placebo or no intervention

Adverse events (AEs; adverse drug reaction): drowsiness/dizziness · patients with acute myocardial infarction

Lidocaine may leads to higher adverse events (AEs; adverse drug reaction): drowsiness/dizziness compared with placebo or no intervention (low certainty).

1 finding from 1 review

Lidocaine vs disopyramide

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with disopyramide (very low certainty).

1 finding from 1 review

Intervention not reported

Survival · patients with unresectable periampullary carcinoma

It is very uncertain whether the intervention changes survival (very low certainty).

1 finding from 1 review

Intervention not reported

Gastric outlet obstruction Clinical symptoms of vomiting with confirmation of the gastric outlet obstruction by radiological or endoscopic investigations · patients with unresectable periampullary carcinoma

It is very uncertain whether the intervention changes gastric outlet obstruction Clinical symptoms of vomiting with… (very low certainty).

1 finding from 1 review