Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol leads to lower adverse events (not including serious adverse events): number of… compared with formoterol (high certainty).
1 finding from 1 review
Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with aclidinium alone (moderate certainty).
1 finding from 1 review
Non‐fatal serious adverse events · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in non‐fatal serious adverse events compared with aclidinium alone (moderate certainty).
1 finding from 1 review
Hospital admissions due to exacerbations: number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in hospital admissions due to exacerbations: number of participants compared with aclidinium alone (moderate certainty).
1 finding from 1 review
Improvement in symptoms: number of participants with clinically significant improvement: using TDI focal score (≥ 1 unit) · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol leads to higher improvement in symptoms: number of participants with clinically… compared with aclidinium alone (high certainty).
1 finding from 1 review
Lung function · patients with chronic obstructive pulmonary disease
1 finding from 1 review
Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in adverse events (not including serious adverse events): number of… compared with aclidinium alone (moderate certainty).
1 finding from 1 review
Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol leads to lower exacerbations requiring steroids or antibiotics or both: number of… compared with formoterol (high certainty).
1 finding from 1 review
Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with chronic obstructive pulmonary disease
Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with formoterol (low certainty).
1 finding from 1 review
Intervention not reported
Pneumonia, community acquired, at least 1 episode · patients with COPD
The intervention probably leads to lower pneumonia, community acquired, at least 1 episode (moderate certainty).
1 finding from 1 review
Intervention not reported
Pneumococcal pneumonia, at least 1 episode · patients with COPD
The intervention showed no clear difference in pneumococcal pneumonia, at least 1 episode (low certainty).
1 finding from 1 review
Intervention not reported
Death from cardiorespiratory causes · patients with COPD
The intervention showed no clear difference in death from cardiorespiratory causes (moderate certainty).
1 finding from 1 review
Intervention not reported
Death from all causes · patients with COPD
The intervention showed no clear difference in death from all causes (moderate certainty).
1 finding from 1 review
Intervention not reported
Hospital admission: any cause, at least 1 episode · patients with COPD
The intervention showed no clear difference in hospital admission: any cause, at least 1 episode (moderate certainty).
1 finding from 1 review
Intervention not reported
COPD exacerbation: at least 1 episode · patients with COPD
The intervention probably leads to lower COPD exacerbation: at least 1 episode (moderate certainty).
1 finding from 1 review
Intervention not reported
Lung function: FEV1 (L) · patients with COPD
1 finding from 1 review
Hospital admissions · COPD
1 finding from 1 review
Acute exacerbations requiring general practitioner (GP) visit and/or additional treatment · COPD
1 finding from 1 review
Health‐related quality of life (HRQoL) · COPD
1 finding from 1 review
Daily step count · COPD
1 finding from 1 review