Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,155 questions · 1,191 findings · 195 reviews · Headline outcomes only

No studies found 209 · 17.5%GRADE not reported 51 · 4.3%Very low 256 · 21.5%Low 273 · 22.9%Moderate 284 · 23.8%High 118 · 9.9%

Hydrus microstent vs iStent trabecular micro‐bypass stent

Proportion of participants who were medication‐free (not using eye drops) short‐term · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication

Hydrus microstent may leads to higher proportion of participants who were medication‐free (not using eye… compared with iStent trabecular micro‐bypass stent (low certainty).

1 finding from 1 review

Hydrus microstent vs iStent trabecular micro‐bypass stent

Mean change in unmedicated IOP (after washout) measured using Goldmann applanation tonometry short‐term · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication
1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Tezepelumab (1 RCT; 56 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in tezepelumab (1 RCT; 56 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

PF‐04965842 (1 RCT; 211 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes PF‐04965842 (1 RCT; 211 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Tralokinumab (1 RCT; 153 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes tralokinumab (1 RCT; 153 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Apremilast (1 RCT; 121 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in apremilast (1 RCT; 121 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 1720 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Fezakinumab (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes fezakinumab (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

QGE031 (1 RCT; 10 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QGE031 (1 RCT; 10 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (2 RCTs; 49 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (2 RCTs; 49 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 13 RCTsTotal participants: 1658 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Corticosteroid (1 RCT; 21 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes corticosteroid (1 RCT; 21 participants) (very low certainty).

1 finding from 1 review