Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Methotrexate vs mycophenolate

Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU

It is very uncertain whether methotrexate changes proportion of participants with confirmed macular edema (lower… compared with mycophenolate (very low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving steroid‐sparing control§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants experiencing complications or requiring cessation of medication (lower number of events is better) · NIIPPU

Methotrexate showed no clear difference in proportion of participants experiencing complications or requiring… compared with mycophenolate (low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Starting administration of the progestogen earlier vs starting administration of the progestogen later

Endometrial thickness (mm) · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

The review found no eligible studies for this question.

1 finding from 1 review

Any systemic treatment vs placebo

Methotrexate · people with chronic plaque psoriasis

Any systemic treatment may leads to higher methotrexate compared with placebo (low certainty).

2 findings from 1 review

Primary objective: mobile stock notification with effective product transport vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of artemether‐lumefantrine 2 X 6 to treat malaria caused by Plasmodium facilparum) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with effective product… changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review

Primary objective: mobile stock notification with enhanced management vs usual care

Proportion of healthcare workers who reported a stockout of drugs in the last 30 days (stockout of artemether‐lumefantrine 2 X 6 to treat malaria caused by Plasmodium facilparum) · healthcare workers and other health professionals involved in commodity and stock management

It is very uncertain whether primary objective: mobile stock notification with enhanced management changes proportion of healthcare workers who reported a stockout of drugs in… compared with standard care (very low certainty).

1 finding from 1 review