What do systematic reviews say?

Subcutaneous insulin aspart vs intravenous regular insulin

Subcutaneous insulin aspart showed no clear difference in hypoglycaemic episodes (N) Mean hospital stay: 3‐5 days compared with intravenous regular insulin (low certainty).

• Subcutaneous rapid‐acting insulin analogues for diabetic ketoacidosis 2016 · Cochrane Headline outcomes only
  RR 1 [0.07, 14.55]
  1 study · 30 participants
  Low

Primary analysis: less vs more frequent

Primary analysis: less showed no clear difference in catheter‐related BSI as defined using criteria specified by Maki… compared with more frequent (low certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 1.06 [0.66, 1.68]
  8 studies · 1794 participants
  Low

Primary analysis: less vs more frequent

Primary analysis: less showed no clear difference in infusate‐related BSI as defined using criteria specified by O'Grady… compared with more frequent (low certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 0.69 [0.31, 1.51]
  11 studies · 1847 participants
  Low

Primary analysis: less vs more frequent

Primary analysis: less showed no clear difference in infusate colonization any positive quantitative culture of infusate compared with more frequent (low certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 1.15 [0.7, 1.86]
  8 studies · 1549 participants
  Low

Primary analysis: less vs more frequent

Primary analysis: less showed no clear difference in catheter colonization any positive semiquantitative or quantitative… compared with more frequent (moderate certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 1.08 [0.94, 1.24]
  4 studies · 1448 participants
  Moderate

Primary analysis: less vs more frequent

Primary analysis: less showed no clear difference in all‐cause BSI any positive blood culture drawn from a peripheral… compared with more frequent (low certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 0.82 [0.48, 1.4]
  6 studies · 2297 participants
  Low

Primary analysis: less vs more frequent

Primary analysis: less may leads to higher mortality compared with more frequent (low certainty).

• Optimal timing for intravascular administration set replacement 2013 · Cochrane Headline outcomes only
  RR 1.85 [1.01, 3.38]
  2 studies · 1355 participants
  Low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

It is very uncertain whether postoperative feeding via nasojejunal tube changes infections (overall) compared with no postoperative parental nutrition (conventional intravenous… (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.32 [0.04, 1.86]
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

It is very uncertain whether postoperative feeding via nasojejunal tube changes infections (bacterial) compared with no postoperative parental nutrition (conventional intravenous… (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.41 [0.03, 3.15]
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

It is very uncertain whether postoperative feeding via nasojejunal tube changes infections (viral) compared with no postoperative parental nutrition (conventional intravenous… (very low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Postoperative feeding via nasojejunal tube vs no postoperative parental nutrition (conventional intravenous electrolyte solution)

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 31 participants
  Very low

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula vs standard isotonic intravenous glucose solution

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula vs standard isotonic intravenous glucose solution

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula vs standard isotonic intravenous glucose solution

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula vs standard isotonic intravenous glucose solution

Parenteral nutrition plus branched‐chain‐amino‐acid‐enriched formula showed no clear difference in mortality [within first 10 weeks after liver transplantation] compared with standard isotonic intravenous glucose solution (low certainty).

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  OR 0.46 [0.01, 10.51]
  1 study · 20 participants
  Low

Standard parenteral nutrition vs standard isotonic intravenous glucose solution

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Low
• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Low

Standard parenteral nutrition vs standard isotonic intravenous glucose solution

• Nutritional interventions for liver‐transplanted patients 2012 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Low