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Evidence found and GRADE certainty

1,078 questions · 1,098 findings · 33 reviews · Skin

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No studies found 396 · 36.1%GRADE not reported 89 · 8.1%Very low 181 · 16.5%Low 183 · 16.7%Moderate 196 · 17.9%High 53 · 4.8%

Azelaic acid vs placebo

Proportion of participants with adverse event · Participants with rosacea
1 finding from 1 review

Azelaic acid vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher physician‐assessed improvement in rosacea severity compared with placebo (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher participant‐assessed improvement in rosacea severity1 Good to… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Proportion of participants with adverse event · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in proportion of participants with adverse event compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg leads to higher physician‐assessed improvement in rosacea severity1 Complete… compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Assessment of erythema or telangiectasia Improved or healed · Participants with rosacea

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

1 finding from 1 review