Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · Dentists managing a defective direct resin composite restoration (posterior occlusal Class I; standardized vignette of a 30-year-old,…
For a defective composite restoration with non-stable (mobile) restoration, surveyed dentists most often preferred replacement over repair (pooled RR 12.17; p < 0.001); ungraded.
1 finding from 1 review
Lumbar spine and pelvis fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 1.058 [0.966, 1.158]
490700 participants
GRADE not reported
OR 1.036 [0.956, 1.122]
490700 participants
GRADE not reported
OR 1.055 [0.983, 1.132]
490700 participants
GRADE not reported
Interleukin-8 (IL-8) · Humans who use e-cigarettes (mostly adults, often with periodontal disease) assessed for oral proinflammatory markers
Meta-analysis suggests no significant effect of e-cigarette use on the salivary level of Interleukin-8 (IL-8) (6 studies), though heterogeneity was high (I2=84%) and the pooled estimate appears only in Figure 3C (unavailable); GCF data were limited (1 study(ies)) (ungraded).
1 finding from 1 review
Osteoporosis · European GWAS participants
The SVMR MR-Egger interval included the null.
4 findings from 1 review
OR 1.001 [0.918, 1.093]
483725 participants
GRADE not reported
OR 0.998 [0.934, 1.067]
483725 participants
GRADE not reported
OR 1.002 [0.925, 1.086]
483725 participants
GRADE not reported
Show 1 more finding
OR 0.998 [0.933, 1.067]
483725 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.985 [0.846, 1.146]
376746 participants
GRADE not reported
OR 1.003 [0.874, 1.151]
376746 participants
GRADE not reported
OR 0.953 [0.813, 1.117]
376746 participants
GRADE not reported
TNF-α level · People who use electronic cigarettes
The review reports no significant e-cigarette effect on salivary TNF-α.
3 findings from 1 review
Cohen's d 0.23 [-0.62, 1.09]
5 studies
GRADE not reported
Cohen's d 2.19 [1.53, 2.84]
2 studies
GRADE not reported
Cohen's d 0.66 [-0.16, 1.43]
7 studies
GRADE not reported
Interleukin-6 (IL-6) · Humans who use e-cigarettes (mostly adults, often with periodontal disease) assessed for oral proinflammatory markers
Meta-analysis suggests no significant effect of e-cigarette use on the salivary level of Interleukin-6 (IL-6) (6 studies), though heterogeneity was high (I2=95%) and the pooled estimate appears only in Figure 3D (unavailable); GCF data were limited (1 study(ies)) (ungraded).
1 finding from 1 review
IL-6 level · People who use electronic cigarettes
The review reports that GCF evidence was limited and may show a potential association.
3 findings from 1 review
Cohen's d 1.43 [0.76, 2.10]
1 study
GRADE not reported
Cohen's d 0.78 [-0.56, 1.98]
5 studies
GRADE not reported
Cohen's d 0.83 [-0.16, 1.79]
6 studies
GRADE not reported
Forearm fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.992 [0.945, 1.042]
490889 participants
GRADE not reported
OR 0.994 [0.948, 1.042]
490889 participants
GRADE not reported
OR 0.990 [0.950, 1.032]
490889 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.062 [0.991, 1.137]
490700 participants
GRADE not reported
Downregulation of S. mutans virulence/biofilm gene expression (gtfB, gtfC, ftf) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
Postbiotics reduce expression of S. mutans biofilm/virulence genes (gtfB, gtfC, ftf) in vitro (ungraded narrative synthesis).
1 finding from 1 review
Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomesExposure 24 h to 7 days · Laboratory (in vitro)
Postbiotics downregulated expression of S. mutans virulence and exopolysaccharide-synthesis genes (e.g., gtfB, gtfC, gtfD, ftf) in 10 in vitro studies; no pooled estimate.
8 studies
GRADE not reported
Osteoporosis with pathological fracture · European-ancestry adults
Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003).
2 findings from 1 review
Salivary S. mutans level · children aged 6 to 12 years
No meta-analysis was conducted; the reduction in salivary Streptococcus mutans count versus fluoride toothpaste was reported as insignificant.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Intervention not reported
Log diagnostic odds ratio
1 finding from 1 review
IL-1β level · People who use electronic cigarettes
The review reports no significant e-cigarette effect on salivary IL-1β.
3 findings from 1 review
Cohen's d 0.87 [-0.33, 2.08]
9 studies
GRADE not reported
Cohen's d 0.98 [-0.03, 1.99]
11 studies
GRADE not reported
Cohen's d 1.58 [-0.79, 3.94]
2 studies
GRADE not reported
Intervention not reported
Reduction of preformed S. mutans biofilms
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Lumbar spine bone mineral density (BMD) · European GWAS participants
The MVMR IVW interval included zero.
1 finding from 1 review
Lumbar spine and pelvis fracture · European-ancestry adults
Genetically predicted periodontitis had no causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 1.060).
2 findings from 1 review
Intervention not reported
Specificity
1 finding from 1 review
Forearm fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 0.992 [0.950, 1.036]
490889 participants
GRADE not reported