Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 884 findings · 229 reviews · Headline outcomes only

No studies found 136 · 15.4%GRADE not reported 37 · 4.2%Very low 242 · 27.4%Low 298 · 33.7%Moderate 131 · 14.8%High 40 · 4.5%

Routine/revealed vs selective/concealed ultrasound

Detection of fetal abnormality before 24 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to higher detection of fetal abnormality before 24 weeks' gestation compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review

Routine/revealed vs selective/concealed ultrasound

Detection of multiple pregnancy by 24 to 26 weeks' gestation (number NOT detected) · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to lower detection of multiple pregnancy by 24 to 26 weeks' gestation (number… compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Readmission for phototherapy for hyperbilirubinemia · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to lower readmission for phototherapy for hyperbilirubinemia compared with visual assessment (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Exchange transfusion · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening showed no clear difference in exchange transfusion compared with visual assessment (low certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Phototherapy before hospital discharge · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening probably leads to higher phototherapy before hospital discharge compared with visual assessment (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening vs visual assessment

Acute bilirubin encephalopathy · newborns for hyperbilirubinemia

Summary of findings table ‐ Transcutaneous bilirubin (TcB) screening showed no clear difference in acute bilirubin encephalopathy compared with visual assessment (low certainty).

1 finding from 1 review

Motivational interviewing vs assessment and feedback

Extent of substance use at short‐term · people with substance use (adults, young adults, adolescents)

The review found no eligible studies for this question.

2 findings from 1 review

Attention deficit hyperactivity disorder (ADHD)‐related drugs vs placebo

Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

The review found no eligible studies for this question.

1 finding from 1 review

Attention deficit hyperactivity disorder (ADHD)‐related drugs vs placebo

Adverse effects · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

It is very uncertain whether attention deficit hyperactivity disorder (ADHD)‐related drugs changes adverse effects compared with placebo (very low certainty).

1 finding from 1 review