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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,206 questions in 117 reviews · Common Mental Disorders
current versionsNo studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Paroxetine vs sertraline Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.94 [0.67, 1.34] | 2 studies · 545 participants | Moderate |
Paroxetine vs agomelatine Failure to remit at endpoint HDRS · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.27 [0.75, 2.14] | 1 study · 284 participants | Moderate |
Paroxetine vs sertraline SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 353 participants | Moderate |
Paroxetine vs sertraline Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.37 [0.52, 3.6] | 2 studies · 426 participants | Moderate |
Paroxetine vs sertraline Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs tianeptine Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.04 [0.71, 1.53] | 3 studies · 648 participants | Moderate |
Paroxetine vs tianeptine Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs tianeptine Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs tianeptine Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.66 [0.18, 2.36] | 1 study · 44 participants | Moderate |
Paroxetine vs tianeptine SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 3 studies · 586 participants | Moderate |
Paroxetine vs tianeptine Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.46 [0.75, 2.85] | 3 studies · 648 participants | Moderate |
Paroxetine vs tianeptine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.26 [0.89, 1.78] | 2 studies · 604 participants | Moderate |
Paroxetine vs agomelatine SMD at endpoint HDRS · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 4 studies · 1074 participants | Moderate |
Paroxetine vs trazodone Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.71 [0.21, 2.41] | 1 study · 108 participants | Moderate |
Paroxetine vs trazodone Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.54 [0.25, 1.19] | 1 study · 108 participants | Moderate |
Paroxetine vs trazodone Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs trazodone Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.06 [0.47, 2.38] | 1 study · 108 participants | Moderate |
Paroxetine vs trazodone SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 108 participants | Moderate |
Paroxetine vs trazodone Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs trazodone Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.68 [0.3, 1.55] | 1 study · 108 participants | Moderate |
Paroxetine vs venlafaxine Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.1 [0.58, 2.11] | 4 studies · 747 participants | Low |
Paroxetine vs venlafaxine Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs venlafaxine Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs agomelatine Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.99 [0.57, 1.71] | 1 study · 284 participants | Moderate |
Paroxetine vs venlafaxine Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.57 [1.08, 2.29] | 4 studies · 807 participants | Moderate |
Paroxetine vs venlafaxine SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 2 studies · 411 participants | Moderate |
Paroxetine vs venlafaxine Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.08 [0.82, 1.44] | 6 studies · 1079 participants | Moderate |
Paroxetine vs venlafaxine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.01 [0.52, 1.95] | 2 studies · 200 participants | Moderate |
Paroxetine vs agomelatine Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.6 [0.99, 2.59] | 1 study · 284 participants | Moderate |
Paroxetine vs amisulpride Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.65 [0.36, 1.15] | 1 study · 277 participants | Moderate |
Paroxetine vs amisulpride Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs amisulpride Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs amisulpride Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.85 [0.49, 1.46] | 1 study · 277 participants | Moderate |
Paroxetine vs amisulpride SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 272 participants | Moderate |
Paroxetine vs older ADs Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.9 [0.61, 1.33] | 4 studies · 526 participants | Low |
Paroxetine vs amisulpride Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs amisulpride Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.49 [0.89, 2.5] | 1 study · 277 participants | Moderate |
Paroxetine vs aprepitant Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs aprepitant Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs aprepitant Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs aprepitant Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.57 [1.08, 2.29] | 4 studies · 807 participants | High |
Paroxetine vs aprepitant SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 102 participants | High |
Paroxetine vs aprepitant Failure to complete ‐ any cause ‐ · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 1.53 [0.76, 3.09] | 1 study · 143 participants | Moderate |
Paroxetine vs aprepitant Participants with at least some Side Effects · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs bupropion Failure to respond at endpoint (6‐12 weeks) · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | OR 0.73 [0.3, 1.79] | 1 study · 100 participants | Moderate |
Paroxetine vs older ADs Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs bupropion Failure to respond at 1‐4 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs bupropion Failure to respond at 16‐24 weeks · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs bupropion Failure to remit at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
Paroxetine vs bupropion SMD at endpoint · patients with depression Paroxetine versus other anti‐depressive agents for depression (2014) · Cochrane | no estimate extracted | 1 study · 132 participants | Moderate |