Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

Protocol‐directed sedation management vs usual care

ICU mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in ICU mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Adverse event ‐ incidence of self‐extubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of self‐extubation (in ICU) compared with usual care (high certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Adverse event ‐ incidence of reintubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of reintubation (in ICU) compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation management vs usual care

Incidence of tracheostomy (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in incidence of tracheostomy (in ICU) compared with usual care (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function ‐ return to independent functional status at hospital discharge Defined as ability to perform 6 ADLs (bathing, dressing, eating, grooming, transferring from bed to chair, using the toilet) and walk independently, · critically ill, mechanically ventilated adults

Early intervention (mobilization or active exercise) may leads to higher physical function ‐ return to independent functional status at… compared with usual care (low certainty).

1 finding from 1 review

Early intervention (mobilization or active exercise) vs usual care

Physical function · critically ill, mechanically ventilated adults
3 findings from 1 review

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults
1 finding from 1 review