Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

870 questions · 912 findings · 85 reviews · Airways

No studies found 65 · 7.1%GRADE not reported 34 · 3.7%Very low 115 · 12.6%Low 273 · 29.9%Moderate 330 · 36.2%High 95 · 10.4%

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in exacerbations requiring steroids or antibiotics or both: number of… compared with aclidinium alone (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs formoterol

Non‐fatal serious adverse events · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in non‐fatal serious adverse events compared with formoterol (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs formoterol

Hospital admissions due to exacerbations: number of participants · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol showed no clear difference in hospital admissions due to exacerbations: number of participants compared with formoterol (moderate certainty).

1 finding from 1 review

Fixed‐dose combination aclidinium/formoterol vs formoterol

Improvement in symptoms: number of participants with clinically significant improvement: using TDI focal score (≥ 1 unit) · patients with chronic obstructive pulmonary disease

Fixed‐dose combination aclidinium/formoterol leads to higher improvement in symptoms: number of participants with clinically… compared with formoterol (high certainty).

1 finding from 1 review