Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,545 questions · 2,661 findings · 317 reviews

No studies found 608 · 22.8%GRADE not reported 505 · 19%Very low 695 · 26.1%Low 540 · 20.3%Moderate 249 · 9.4%High 64 · 2.4%

Potassium citrate vs no intervention

Proportion of participants who developed a new urinary stone · children with idiopathic urinary calculi treated with shockwave lithotripsy

Potassium citrate may leads to lower proportion of participants who developed a new urinary stone compared with no intervention (low certainty).

1 finding from 1 review

Potassium citrate vs no intervention

Proportion of participants with adverse events while undergoing intervention · children with idiopathic urinary calculi treated with shockwave lithotripsy

It is very uncertain whether potassium citrate changes proportion of participants with adverse events while undergoing… compared with no intervention (very low certainty).

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Primary care physician alerting system vs usual care

Bone mineral density · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system probably leads to higher bone mineral density1 compared with usual care (moderate certainty).

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Marginal bone level change · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in 1-year post-loading bone level changes compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

2 findings from 1 review

Vertical distraction osteogenesis vs Autogenous inlay bone graft (iliac crest)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis led to higher vertical bone gain compared with autogenous inlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Vertical distraction osteogenesis vs Autogenous onlay bone graft (mandibular ramus)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical distraction osteogenesis showed no clear difference in vertical bone gain compared with autogenous onlay bone graft (mandibular ramus); GRADE not reported.

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with AC of the esophagus

Summary of findings table (subcomparison 5): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review