Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Conrotto 2006: ciclosporin - skin rashes (2), parotid swelling (1), and dyspepsia (3); clobetasol - dyspepsia (1).
1 study · 40 participants
GRADE not reported
Any topical or systemic intervention vs Placebo, no treatment, or another intervention
Outcome not reported · People with erosive oesophageal lichen planus
The review found no eligible studies for this question.
1 finding from 1 review
Pain, number of ulcers, ulcer-free days and ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
A single trial at high risk of bias compared pentoxifylline 400 mg three times daily (n=14) with placebo (n=12). No statistically significant differences were reported for pain, number of ulcers and ulcer-free days at…
1 study · 26 participants
GRADE not reported
Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus
Aloe vera gel showed no clear difference in physician Global Assessment (Thongprasom score) compared with placebo; GRADE not reported.
1 finding from 1 review
Complete remission (no further aphthous episodes to 6 months) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
The trial by de Abreu 2009 (high risk of bias) also assessed colchicine (n=23) versus placebo (n=20). The number with no further aphthous episodes at 6 months was not significantly different from placebo (Fisher's…
1 study · 43 participants
GRADE not reported
Primary outcome: partial clinical response · People with erosive oral lichen planus
Aloe vera gel led to higher partial response (>=50% clinical improvement) compared with placebo; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Choonhakarn 2008: no serious side-effects; 2 participants receiving aloe vera gel reported stinging and mild itching at lesions within the first week, symptoms spontaneously disappeared with…
1 study · 45 participants
GRADE not reported
Pain free by end of study (day 6) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
Individualised homeopathic medicine (two doses over 24 hours) led to higher pain free by end of study (day 6) compared with placebo; GRADE not reported.
1 finding from 1 review
Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus
Betamethasone oral mini-pulse therapy led to higher physician Global Assessment (clinical severity, 0-12 score) compared with topical triamcinolone acetonide 0.1% paste; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Hegarty 2002: nausea (4), swollen mouth (1), bad taste and smell (6), difficulty in spray application (7), dry mouth (2), sore throat (1), red painful tongue (1), and pseudomembranous…
1 study · 44 participants
GRADE not reported
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
Reduction in severity of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions
The review found no eligible studies for this question.
1 finding from 1 review
Physician Global Assessment (Thongprasom score) · People with erosive oral lichen planus
Clobetasol-17-propionate 0.025% lipid-loaded microspheres showed no clear difference in physician Global Assessment (Thongprasom score) compared with conventional 0.025% clobetasol lipophilic ointment in hydrophilic…; GRADE not reported.
1 finding from 1 review
Thalidomide (immunomodulator) vs Placebo or no treatment
Outcome not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
The review found no eligible studies for this question.
1 finding from 1 review
Authors' conclusions: 'this review did not find trials involving several of other systemic interventions used for RAS, for example thalidomide in the absence of any systemic condition, despite its limitations on…
0 studies
No studies found
Pain reduction (VAS) · People with erosive oral lichen planus
1% pimecrolimus cream showed no clear difference in pain reduction (VAS) compared with placebo (vehicle cream); GRADE not reported.
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · People with erosive oral lichen planus
Topical ciclosporin 1.5% gel showed no clear difference in pain (>=50% improvement in symptoms) compared with topical clobetasol propionate 0.025% gel; GRADE not reported.
1 finding from 1 review
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
Clofazimine was associated with an increase in cutaneous adverse effects (skin pigmentation and drying) (Fisher's exact test P=0.015), but these were reported to be easily controlled.
1 study · 43 participants
GRADE not reported
Number of days of ulcers (monthly average) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
LongoVital (herbal component alone) showed no clear difference in number of days of ulcers (monthly average) compared with placebo; GRADE not reported.
1 finding from 1 review
Side effects · People with erosive oral lichen planus
1 finding from 1 review
Table 3 (Side-effects). Lin 2005: TGT - menstrual disturbance (6) and leucopenia (1). Tripterygium glucosides are known to be cytotoxic and unsuitable for individuals of child-bearing age.
1 study · 94 participants
GRADE not reported
Side effects · People with erosive oral lichen planus
1 finding from 1 review