Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

949 questions · 1,008 findings · 130 reviews · Gynaecology and Fertility

No studies found 195 · 19.3%GRADE not reported 30 · 3%Very low 346 · 34.3%Low 323 · 32%Moderate 101 · 10%High 13 · 1.3%

Dose comparison: oestrogen 100 µg patch vs 200 µg patch plus progestogen

Adverse events ‐ specific side effects attributed to oestrogen over 8 months' · women with PMS

It is very uncertain whether dose comparison: oestrogen 100 µg patch changes adverse events ‐ specific side effects attributed to oestrogen over… compared with 200 µg patch plus progestogen (very low certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Ease of dilatation: need for mechanical dilatation · Pre and post menopausal women

Misoprostol probably leads to lower ease of dilatation: need for mechanical dilatation compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Cervical laceration/tear · Pre and post menopausal women

Misoprostol probably leads to lower specific intraoperative complications ‐ Cervical laceration/tear compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ False track · Pre and post menopausal women

Misoprostol probably leads to lower specific intraoperative complications ‐ False track compared with placebo or no treatment before operative hysteroscopy (moderate certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Uterine perforation · Pre and post menopausal women

Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine perforation compared with placebo or no treatment before operative hysteroscopy (low certainty).

1 finding from 1 review

Misoprostol vs placebo or no treatment before operative hysteroscopy

Specific intraoperative complications ‐ Uterine bleeding · Pre and post menopausal women

Misoprostol showed no clear difference in specific intraoperative complications ‐ Uterine bleeding compared with placebo or no treatment before operative hysteroscopy (low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus ISMI (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus ISMI (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Universal IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Universal IVF (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus Vitrolife (IVF or G3) (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

The intervention showed no clear difference in early embryo transfer: Cook (K‐SIFM or K‐SICM) (specific) versus… (low certainty).

1 finding from 1 review

Intervention not reported

Early embryo transfer ‐ G2 (specific) versus Ham's F10 (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes early embryo transfer ‐ G2 (specific) versus Ham's F10 (other) (very low certainty).

1 finding from 1 review

Intervention not reported

Late embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) · Women in assisted reproductive technology cycles (ART) receiving human pre‐implantation embryos in either early (cleavage stage transfer)…

It is very uncertain whether the intervention changes late embryo transfer ‐ GM501 (specific) versus Sydney IVF (other) (very low certainty).

1 finding from 1 review