Findings

What do systematic reviews say?

805 questions · 838 findings · 55 reviews · Wounds

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No studies found 354 · 42.2%GRADE not reported 38 · 4.5%Very low 283 · 33.8%Low 132 · 15.8%Moderate 27 · 3.2%High 4 · 0.5%

NPWT 125 mmHg vs usual care

Adverse events · open fracture wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 460 participants
GRADE not reported

NPWT 125 mmHg vs usual care

Time to closure or coverage surgery · open fracture wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 151 participants
Very low

NPWT 125 mmHg vs usual care

Pain · open fracture wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Wound infection · other open traumatic wounds

NPWT 125 mmHg showed no clear difference in wound infection compared with standard care (low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.61 [0.31, 1.18]
2 studies · 509 participants
Low

NPWT 125 mmHg vs usual care

Adverse events · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Time to closure or coverage surgery · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

All irrigation vs no irrigation

Surgical site infection · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

All irrigation showed no clear difference in SSI compared with no irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.87 [0.68, 1.11]
14 studies · 6106 participants
Low

Standard irrigation vs pulsatile irrigation

Wound dehiscence · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Standard irrigation showed no clear difference in wound dehiscence compared with pulsatile irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.31 [0.01, 7.55]
1 study · 128 participants
Low

Standard irrigation vs pulsatile irrigation

Adverse events · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Standard irrigation showed no clear difference in adverse events compared with pulsatile irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 1.31 [0.87, 1.97]
1 study · 128 participants
Low

Standard irrigation vs pulsatile irrigation

Adverse events: abscess formation · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

The review found no eligible studies for this question.

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

All irrigation vs no irrigation

Wound dehiscence · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

All irrigation showed no clear difference in wound dehiscence compared with no irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 1.17 [0.44, 3.06]
1 study · 30 participants
Low

All irrigation vs no irrigation

Adverse events · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

All irrigation showed no clear difference in adverse events compared with no irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 1.05 [0.76, 1.44]
3 studies · 403 participants
Low

All irrigation vs no irrigation

Adverse events: abscess formation · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

All irrigation showed no clear difference in adverse events: abscess formation compared with no irrigation (moderate certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.91 [0.54, 1.54]
3 studies · 331 participants
Moderate

Irrigation with antibacterial solution vs irrigation with non‐antibacterial solution

Surgical site infection · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Irrigation with antibacterial solution may leads to lower SSI compared with irrigation with non‐antibacterial solution (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.57 [0.44, 0.75]
30 studies · 5141 participants
Low

Irrigation with antibacterial solution vs irrigation with non‐antibacterial solution

Wound dehiscence · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

It is very uncertain whether irrigation with antibacterial solution changes wound dehiscence compared with irrigation with non‐antibacterial solution (very low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 1.26 [0.65, 2.45]
3 studies · 660 participants
Very low

Irrigation with antibacterial solution vs irrigation with non‐antibacterial solution

Adverse events · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Irrigation with antibacterial solution showed no clear difference in adverse events compared with irrigation with non‐antibacterial solution (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.55 [0.22, 1.34]
3 studies · 178 participants
Low

Irrigation with antibacterial solution vs irrigation with non‐antibacterial solution

Adverse events: abscess formation · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

It is very uncertain whether irrigation with antibacterial solution changes adverse events: abscess formation compared with irrigation with non‐antibacterial solution (very low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.82 [0.42, 1.62]
9 studies · 1309 participants
Very low

Standard irrigation vs pulsatile irrigation

Surgical site infection · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

Standard irrigation may leads to lower SSI compared with pulsatile irrigation (low certainty).

1 finding from 1 review

Intracavity lavage and wound irrigation for prevention of surgical site infection 2017 · Cochrane Headline outcomes only
RR 0.34 [0.19, 0.62]
2 studies · 484 participants
Low

Mupirocin ointment vs placebo

Surgical site infection · S aureus carriers undergoing cardiac surgery

Mupirocin showed no clear difference in SSI compared with placebo (low certainty).

1 finding from 1 review

Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers 2017 · Cochrane Headline outcomes only
RR 1.6 [0.79, 3.25]
1 study · 257 participants
Low