Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Antibiotics vs placebo

Pain ‐ pain at 2 to 3 days · children with acute otitis media

Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 4 to 7 days · children with acute otitis media

Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 10 to 12 days · children with acute otitis media

Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).

1 finding from 1 review