Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged one to 12 years old

IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

Supplementary feeding vs no food supplementation or placebo

Weight‐for‐length/height z‐score at the end of the intervention Weight scale, measurement boards and child growth reference · Children aged less than five years with or without stunting/wasting in LMIC
1 finding from 1 review

Supplementary feeding vs no food supplementation or placebo

Weight‐for‐length/height z‐score at the end of the intervention Weight scale, measurement boards and child growth reference · Children aged less than five years in LMIC
2 findings from 1 review