Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,192 questions · 1,243 findings · 151 reviews

No studies found 252 · 20.3%GRADE not reported 180 · 14.5%Very low 291 · 23.4%Low 282 · 22.7%Moderate 174 · 14%High 64 · 5.1%

Daily aural toileting vs single aural toileting episode

Frequency of adverse effects ‐ dizziness ( · people (of any age) with otorrhoea for a duration of at least 6 weeks

It is very uncertain whether daily aural toileting changes adverse events: dizziness Assessed by: self reported compared with single aural toileting episode (very low certainty).

1 finding from 1 review

Daily aural toileting vs single aural toileting episode

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with otorrhoea for a duration of at least 6 weeks

It is very uncertain whether daily aural toileting changes resolution of ear discharge ‐ 1 to 2 weeks Assessed by: unknown ‐… compared with single aural toileting episode (very low certainty).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Total number of ibuprofen tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of ibuprofen tablets compared with placebo plus analgesic (low certainty).

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Patient-reported pain intensity (sum of pain intensity difference (SPID) and sum of pain percussion intensity difference (SPPID)) · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis
1 finding from 1 review
  • Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes
    7 days
    Corresponding risk (Antibiotics): The in between-group differences (median +/- IQR) in SPID for the penicillin group were 6.0 +/- 10.5, and for placebo 6.0 +/- 9.5. The SPPID for the penicillin group was 3.5 +/- 7.5…
    1 study · 40 participants
    Low

Intervention not reported

Preterm birth < 37 weeks · singleton pregnancy with symptoms of PTL

It is very uncertain whether the intervention changes preterm birth < 37 weeks (very low certainty).

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Non‐initiation of breastfeeding · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

The review found no eligible studies for this question.

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Exclusive breastfeeding at 4‐6 weeks · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

It is very uncertain whether physical breastfeeding support interventions (electric or manual… changes exclusive breastfeeding at 4‐6 weeks compared with usual care (no pump) (very low certainty).

1 finding from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Breastfeeding · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

It is very uncertain whether physical breastfeeding support interventions (electric or manual… changes any breastfeeding at 4‐6 weeks compared with usual care (no pump) (very low certainty).

2 findings from 1 review

Physical breastfeeding support interventions (electric or manual breast pump) vs usual care (no pump)

Exclusive breastfeeding at 6 months · women with a pre‐pregnancy BMI > 29 kg/m², who were intending to breastfeed, had no history of breast surgery, who were at least 19 years…

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Total number of paracetamol (acetaminophen) with codeine (Tylenol) tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of paracetamol (acetaminophen) with codeine (Tylenol)… compared with placebo plus analgesic (low certainty).

1 finding from 1 review

ADMG + CAF vs CAF

Occurrence of adverse effects or postoperative complications · Adult patients with single (localised) recession-type defects (Miller Class I/II, at least 3 mm)
1 finding from 1 review